Determination of Molecular Mass Service

Determination of molecular mass involves accurately measuring the mass of molecules or complexes using precise analytical techniques. This process is essential for molecular structure analysis, drug development, materials science, and various other fields. Accurate molecular mass data reveal a molecule's composition, stability, and functional characteristics, serving as the foundation for numerous scientific studies.

 

MtoZ Biolabs integrates advanced technologies such as mass spectrometry (MS), gel permeation chromatography (GPC), and dynamic light scattering (DLS) to offer high-precision molecular mass determination services. Our expertise supports clients in making significant advancements in drug development, molecular analysis, and related areas.

 

Services at MtoZ Biolabs

MtoZ Biolabs provides comprehensive Determination of Molecular Mass Service by leveraging multiple technological platforms to ensure precise analysis of diverse samples. Our key techniques include:

Mass Spectrometry (MS): Utilizing ESI or MALDI in conjunction with high-resolution mass spectrometers such as Orbitrap and FTICR MS, we accurately determine the molecular masses of small molecules, proteins, peptides, and other compounds.

 

Gel Permeation Chromatography (GPC): By separating samples based on molecular size and combining with light scattering or UV detection, we analyze the molecular masses of large molecules, including proteins, polymers, and nucleic acids. This technique is extensively applied in the determination of polymers and colloidal solutions.

 

Dynamic Light Scattering (DLS): DLS measures the particle size and molecular mass of colloids and large molecules by analyzing the Brownian motion of particles, providing quantitative data on molecular dimensions and mass.

 

Light Scattering (LS): Through the analysis of scattered light, LS provides information on particle size and molecular mass, making it particularly suitable for studying large molecules such as polymers and colloidal solutions.

 

Ultra-High Performance Liquid Chromatography (UHPLC): UHPLC is ideal for separating small molecule compounds and large biomolecules within complex biological samples. It delivers precise molecular mass data through high-resolution analysis.

 

By integrating these technologies, MtoZ Biolabs offers comprehensive molecular mass analysis, ensuring data accuracy and reliability.

 

Why Choose MtoZ Biolabs?

1. Comprehensive Technological Integration: MtoZ Biolabs combines Mass Spectrometry, GPC, DLS, and other advanced technologies to accommodate various sample types, delivering thorough molecular mass analyses.

2. Versatility Across Sample Types: From small molecule compounds to complex biological macromolecules, we provide accurate molecular mass determinations tailored to your needs.

3. Customized Analytical Solutions: We offer personalized analysis plans based on client requirements, ensuring each molecular mass determination aligns with specific research or application objectives.

4. High-Data-Quality: Deep data coverage with strict data quality control. AI-powered bioinformatics platform integrate all proteomics analysis data providing clients with a comprehensive data report.

5. One-Time-Charge: Our pricing is transparent, no hidden fees or additional costs.

 

Sample Submission Suggestions

MtoZ Biolabs accepts a wide range of samples for molecular mass determination, including but not limited to:

• Chemical Small Molecules
• Proteins and Peptides
• Nucleic Acids (DNA/RNA)
• Carbohydrates and Lipids
• Protein Complexes and Antibody-Drug Conjugates (ADC)

 

Please consult with MtoZ Biolabs' customer service team beforehand to verify sample concentration, physical state, and specifications, ensuring they meet experimental requirements.

 

Applications

MtoZ Biolabs' Determination of Molecular Mass Service is utilized across various industries and research fields, including:

• Drug Development: Delivering precise molecular mass data for drug candidates and metabolites to support drug screening, pharmacodynamics studies, and efficacy research.
• Chemical Analysis: Providing molecular mass information for small molecules and polymers, facilitating the development of new materials and quality assurance processes.
• Biopharmaceuticals: Conducting quality assessments of biological macromolecules such as proteins, antibodies, and vaccines to ensure their stability and integrity.
• Quality Control: Offering molecular mass data for raw materials, intermediates, and final products during manufacturing to maintain compliance with quality standards.
• Environmental Monitoring: Supplying molecular mass information for pollutants and toxic substances, aiding in environmental surveillance and risk assessment efforts.

 

Case Study

1. Molecular Mass Determination of Proteins and Complexes in a Single Human Erythrocyte by Mass Spectrometry

 



Waka, S. et al. Anal. Chem. 2021.

 

FAQ

Q1: How much sample should I submit for molecular weight determination analysis?

The required sample volume depends on the analytical technique and sample type. Generally, only a few microliters or milligrams are needed for small molecules, while proteins and larger molecules may require concentrations of 1-10 mg/mL. Sample volume is tailored to your project’s specific needs and selected method. We recommend consulting our technical support team before submission to confirm that the sample volume and concentration align with optimal testing conditions.

 

Deliverables

1. Comprehensive Experimental details

2. Materials, Instruments, and Methods

3. Total Ion Chromatogram & Quality Control Assessment

4. Data Analysis, Preprocessing, and Estimation

5. Bioinformatics Analysis

6. Raw Data Files

 

MtoZ Biolabs, an integrated Chromatography and Mass Spectrometry (MS) Services Provider, provides advanced proteomics, metabolomics, and biopharmaceutical analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. Our ultimate aim is to provide more rapid, high-throughput, and cost-effective analysis, with exceptional data quality and minimal sample consumption. Free project evaluation, welcome to learn more details!