Custom Chemical Probe Synthesis Service

Chemical probes refer to a class of highly target-selective small molecules that can specifically modulate the function of target proteins in vitro or in vivo. These molecules help scientists understand the biological roles of target proteins, assess their druggability, and provide structural starting points for drug development. In modern drug discovery workflows, chemical probes are widely used in target validation, mechanism exploration, pathway analysis, disease model intervention, and pharmacological prediction. Serving as a bridge between basic research and drug development, chemical probes play an essential role in areas such as targeted therapy, epigenetics, and protein degradation.

 

As a CRO specializing in custom chemical synthesis, MtoZ Biolabs offers a Custom Chemical Probe Synthesis Service, leveraging advanced synthesis platforms and analytical capabilities. This service is tailored for academic institutions, pharmaceutical companies, and innovative drug discovery teams, delivering efficient and reliable probe synthesis solutions.

 

Services at MtoZ Biolabs

MtoZ Biolabs provides end-to-end custom chemical probe synthesis service, covering probe design, route planning, compound synthesis, structural characterization, and purity confirmation. Our offerings support various research applications:

1. Custom synthesis of reversible or covalent chemical probes

2. PROTAC-based bifunctional probe design and synthesis

3. Covalent probes with reactive warheads for active site labeling

4. Fluorescent, photoactivatable, and affinity-labeled probe construction

5. Biotin, BODIPY, and other tagged probe synthesis

6. Fragment-based derivatized probe development

 

Clients may provide a target structure, reference literature, or biological target information. Our synthetic team will handle design, route optimization, and compound preparation to meet research needs while ensuring efficiency and purity.

 

Analysis Workflow

MtoZ Biolabs follows a standardized workflow to ensure quality and reproducibility across projects:

 



 

Service Advantages

1. Comprehensive Probe Synthesis Solutions

Our team is experienced in synthesizing diverse types of chemical probes, including PROTACs, covalent inhibitors, and fluorescent-tagged compounds. These are widely applicable in proteomics, chemical biology, and pharmacological research. We also support structural modifications based on client hypotheses.

 

2. Standardized Project Workflow

Each synthesis follows a traceable and documented procedure. We provide clients with complete compound data, including purity metrics, structural validation, and experimental summaries to facilitate publications and downstream development.

 

3. Integrated Analytical Platform

With access to state-of-the-art mass spectrometry, NMR, and chromatography facilities, every probe is rigorously characterized for structure and purity, minimizing the risk of downstream experimental variability or failure.

 

4. Flexible Project Scale

We support orders starting from milligram scale for early-stage exploratory studies and can scale up to gram-level synthesis for animal studies or screening campaigns. Our flexible service model adapts to your research stage and resource needs.

 

5. Cross-Disciplinary Collaboration

Our team has extensive experience collaborating across medicinal chemistry, proteomics, metabolomics, and bioinformatics. We help clients develop tailored probe strategies that support both molecular design and biological function discovery.

 

Applications

MtoZ Biolabs' custom chemical probes are applicable across multiple research domains:

1. Target validation and mechanism of action studies

2. Pathway mapping and regulatory network analysis

3. PROTAC-mediated protein degradation studies

4. Fluorescence imaging and subcellular localization research

5. Protein–protein interaction labeling and screening

6. Active site identification and structural perturbation analysis

 

FAQ

Q1: I only have the target protein information, not a compound structure. Can you help?

Yes. You can provide the target protein and functional data, and we will assist in molecular design, synthesis planning, and feasibility assessment.

 

Q2: Do you offer probes labeled with biotin or fluorophores?

Yes. We can incorporate biotin, BODIPY, Cy3, and other tags to suit applications such as pull-down assays and live-cell imaging.

 

Q3: What is the typical turnaround time?

Our standard delivery time ranges from 3 to 6 weeks depending on compound complexity and reaction challenges.

 

Q4: Do you support confidentiality agreements?

Yes. We offer CDAs (Confidential Disclosure Agreements) to protect your intellectual property and project details.

 

Deliverables

Upon completion, MtoZ Biolabs provides a comprehensive data package suitable for downstream experimentation, patent submission, or publication:

1. Final synthesized compound (solid or solution, packaged as required)

2. NMR spectra (¹H and/or ¹³C) for structure verification

3. Mass spectrometry data (MS) for molecular weight confirmation

4. HPLC or UPLC analysis report for purity assessment

5. Experimental summary including reaction conditions and yield

6. (Optional) SDS and storage/use recommendations if applicable

 

Chemical probes are powerful tools in modern biomedical research, facilitating drug discovery, mechanism elucidation, and biological modulation. With standardized workflows and reliable synthesis capabilities, MtoZ Biolabs is your trusted partner for custom chemical probe development. Contact us today for a free project evaluation or consultation—let's advance your molecular research together.