Centrosome Analysis Services
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- Global protein expression profiling under specific conditions
- Functional enrichment and pathway network analysis
- Protein–protein and protein–DNA interaction identification
- Post-translational modification (PTM) mapping (e.g., phosphorylation, ubiquitination)
- Structural predictions and subcellular localization analysis
- DDA/DIA-based discovery of novel centrosomal proteins
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- Precise quantification via MRM, PRM, and other methods
- Untargeted metabolite discovery for novel biomarker identification
- Metabolite classification, quantitation, differential analysis, and pathway mapping
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- High-coverage lipid species identification and quantification
- Profiling of lipid composition shifts under various stimuli
- Functional interpretation of lipid signaling pathways linked to centrosomal activity
The centrosome is a master regulator of cellular architecture and dynamics. As the primary microtubule-organizing center (MTOC), it plays an indispensable role in spindle formation, chromosome segregation, and cell cycle progression. Beyond mitotic regulation, centrosomes are deeply involved in establishing cell polarity, orchestrating signal transduction, and maintaining intracellular spatial organization. Their structural and functional integrity is vital for genomic stability and normal cellular physiology.
Mounting evidence has linked centrosomal abnormalities to a spectrum of pathological conditions, including cancer, neurodegenerative diseases, and ciliopathies. Disruption in centrosome number, structure, or composition can trigger chromosomal instability, cell polarity defects, and aberrant signaling—key events in disease pathogenesis. Therefore, high-resolution, multi-dimensional characterization of centrosomes is critical for both basic and translational research.
MtoZ Biolabs delivers specialized Centrosome Analysis Services powered by advanced proteomics, metabolomics, and lipidomics platforms. We provide tailored, high-throughput solutions that enable researchers to dissect the molecular composition, functional states, and dynamic regulatory mechanisms of centrosomes under various biological contexts.
Services at MtoZ Biolabs
Our Centrosome Analysis Services provide integrated multi-omics solutions to systematically profile the composition and functional landscape of centrosomes at the protein, metabolite, and lipid levels.
· Centrosome Isolation and Purification Services
We employ optimized differential and density gradient centrifugation strategies to isolate centrosomes with high purity from a variety of biological specimens. Protein extraction protocols are precisely tuned for compatibility with downstream omics workflows, ensuring optimal sample integrity and reproducibility.
· Centrosomal Proteomics Analysis
Leveraging high-resolution LC-MS/MS systems such as the Thermo Orbitrap Fusion Lumos, we offer comprehensive proteomic solutions, including:
· Centrosomal Metabolomics Analysis
Our metabolomics services capture the biochemical microenvironment of the centrosome using both targeted and untargeted MS approaches:
· Centrosomal Lipidomics Analysis
Given the centrosome’s proximity to membrane systems and its role in lipid-modulated processes, we offer:
Why Choose MtoZ Biolabs?
✔ Integrated Multi-Omics Solutions: We combine proteomics, metabolomics, and lipidomics to provide a comprehensive view of centrosome biology.
✔ Advanced Instrumentation: Our platform includes the Thermo Orbitrap series and triple quadrupole mass spectrometers, supporting full-spectrum and targeted analyses.
✔ Broad Sample Compatibility: We work with a wide range of sample types, including cell lines, tissues, and animal models.
✔ Expert Bioinformatics Support: Our bioinformatics team delivers complete data analysis pipelines, including quantification, differential expression, and functional annotation.
✔ Transparent, One-Time Pricing: We provide clear, one-time project quotations—no hidden costs, no surprise fees.
Applications
· Cancer Biology: Explore centrosome amplification, spindle assembly defects, and CIN in tumor initiation and progression
· Neuroscience: Investigate centrosome-driven polarity defects and migration disorders in neurodevelopmental and neurodegenerative contexts
· Ciliopathies: Analyze defects in centriole–basal body transition and ciliary assembly linked to multisystem disorders
· Cell Cycle Research: Monitor centrosomal protein dynamics and PTM changes across cell cycle phases
· Drug Discovery: Assess how compounds modulate centrosome-related pathways involved in microtubule dynamics and cell division
FAQ
Q1: How are centrosomal defects implicated in tumorigenesis?
Aberrant centrosome number or structure is a hallmark of many cancers. These abnormalities can disrupt mitotic fidelity, cause chromosome missegregation, and promote chromosomal instability—key drivers of tumor evolution. MtoZ Biolabs provides integrated omics approaches to delineate these changes at the molecular level, offering insights into the mechanistic underpinnings of centrosome-related oncogenesis.
Q2: Can you support comparative analysis across multiple time points or treatments?
Absolutely. We offer both label-free and TMT-labeled quantification strategies for multi-condition comparisons, enabling precise profiling of centrosome responses to external stimuli, genetic perturbations, or pharmacological treatments.
What Could be Included in the Report?
1. Comprehensive Experimental Details
2. Materials, Instruments, and Methods
3. Total Ion Chromatogram & Quality Control Assessment
4. Data Analysis, Preprocessing, and Estimation
5. Bioinformatics Analysis
6. Raw Data Files
In addition to our Centrosome Analysis Services, MtoZ Biolabs provides specialized omics profiling for a range of subcellular compartments, including mitochondria, ER, Golgi apparatus, lysosomes, peroxisomes, and nuclei. Our organelle-focused solutions combine advanced fractionation methods with multi-omics technologies to deliver accurate, reproducible insights into organelle function, crosstalk, and disease relevance.
Empower your research with MtoZ Biolabs—your trusted partner in high-resolution organelle biology.
Related Services
Mitochondrial Analysis Services
How to order?
