Cell Surface Proteomics Analysis Service
Cell surface proteins (SPs) are proteins that span, anchor, or embed in the plasma membrane, mediating communication between the cell and its extracellular environment. SPs perform specific functions on the cell membrane, including nutrient and ion transport, cell-cell interactions, receptor-mediated signal transduction, enzymatic reactions, and immune recognition. Due to their critical biological roles and unique subcellular localization, SPs are considered key structures for identifying targets in immunotherapy and targeted therapy.
MtoZ Biolabs offers cell surface proteomics analysis service utilizing multiple SP labeling and enrichment technologies, such as surface biotinylation site identification technology (sBioSITe) combined with high-pH reversed-phase StageTip fractionation and extensive data analysis expertise. In recent years, research in cell surface proteomics has significantly advanced technologies in targeted therapy, immunotherapy, vaccine development, and cell sorting.
Shuster, S A. et al.Neuron, 2022.
Figure 1. Methods for Cell Type-Specific Cell Surface Proteomics Analysis in Tissues.
Service Advantages
1. Advanced Analytical Platform
MtoZ Biolabs utilizes Thermo Fisher’s Orbitrap Fusion Lumos mass spectrometry platform combined with nano LC-MS/MS technology, establishing cell surface proteomics analysis service platform to deliver efficient and precise cell surface protein analysis services.
2. High-Quality Data
We provide comprehensive solutions tailored to various sample types, offering extensive bioinformatics analyses, including cell surface protein quantification, modification analysis, and de novo peptide/protein sequencing. Our services also integrate multi-omics approaches to maximize data value.
3. Transparent Pricing
Our pricing is transparent, with no hidden or additional fees.
4. Customized Research Solutions
MtoZ Biolabs offers personalized services tailored to your samples, addressing diverse research questions and experimental requirements.
Sample Submission Suggestions
1. Sample Types
Fresh tissues or cells, preferably stored and transported on dry ice.
2. Sample Amount
We recommend preparing at least three biological replicates.
Note: For special requirements or assistance with sample preparation, please contact us.
Applications
1. Disease Biomarkers and Drug Targets
Cell surface proteomics analysis service can differentiate cellular phenotypes and disease states, serving as biomarkers and drug targets for various diseases.
2. Immunotherapy and Vaccine Development
Advances in cell surface proteomics drive progress in targeted therapy, immunotherapy, and vaccine development. For instance, identifying tumor-specific surface proteins enables the development of targeted immunotherapeutic strategies.
3. Cell Sorting and Flow Cytometry
Cell surface proteins serve as markers for cell sorting and flow cytometry, aiding in the identification and isolation of specific cell populations, which is crucial for cell biology research and clinical diagnostics.
4. Development of New Techniques and Methods
To further advance the cell surface proteomics analysis service developing, several innovative techniques and methods have been developed. For instance, the chemical proteomics approach for live-cell surface functional amino acid analysis enables the global identification of functional lysine residues on live cell surfaces. Additionally, the peroxidase-catalyzed cell surface protein rapid labeling strategy (PECSL) facilitates the efficient labeling of cell surface proteins within a short time frame.
MtoZ Biolabs, an integrated Chromatography and Mass Spectrometry (MS) Services Provider, provides advanced proteomics, metabolomics, and biopharmaceutical analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. Our ultimate aim is to provide more rapid, high-throughput, and cost-effective analysis, with exceptional data quality and minimal sample consumption. Free project evaluation, welcome to learn more details!
MtoZ Biolabs, an integrated chromatography and mass spectrometry (MS) services provider.
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