Yellow Skin: Glycation? MtoZ Biolabs Unravels the Mystery

Skin - an essential part of our body, not only a marker of external beauty, but also an important reflection of our health status. Glycation is a natural process in the human body that occurs when sugars such as glucose or fructose bind with skin's collagen and elastin proteins, making the skin's collagen stiff, causing the skin to lose its natural structural support, resulting in wrinkles, fine lines, and sagging. Skin glycation is a non-enzymatic biochemical process that involves the reaction between the sugars in the skin and proteins (such as collagen and elastin). So, does yellowing skin necessarily mean glycation?

 

The answer is not necessarily, skin yellowing may have other causes, usually associated with the amount of bilirubin in the body. Bilirubin is a product of the breakdown of old red blood cells; if red blood cells die or decompose excessively, the liver is burdened or damaged, or if the bilirubin in the liver cannot enter the digestive tract normally, increased bilirubin causes the skin and mucous membranes to turn yellow, known as jaundice. The identification of skin glycation and bilirubin metabolites, as a key link in skin health research, is of great significance for understanding and diagnosing various skin diseases.

 

MtoZ Biolabs, with years of deep plowing in metabolomics, has a professional and compliant technical platform and a complete service process, provides a one-stop metabolomics service for you. By detecting small molecule metabolites in skin tissue, it can provide scientific basis for skin pathology and skin care.

 

Why Choose MtoZ Biolabs' Collagen Glycation and Bilirubin Identification Technology?

1. Professional Technology

Combined with Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and Nuclear Magnetic Resonance (NMR) technology, it can accurately analyze and identify skin glycation products and metabolites such as bilirubin.

 

2. Comprehensive Analysis

Not only can identify the degree of collagen glycation, but also accurately identify the presence and specific content of bilirubin, provide comprehensive information of skin pathological state, and find the real cause of skin yellowing.

 

3. Professional Team

A team composed of experts with rich background in skin biology and analytical chemistry, providing full-range services from sample handling to data analysis.

 

Application Range of Collagen Glycation and Bilirubin Identification Technology

1. Skin Aging Research

By analyzing skin glycation products, the degree and mechanism of skin aging can be evaluated.

 

2. Skin Disease Diagnosis

Analysis of bilirubin helps in diagnosing and monitoring skin diseases such as jaundice.

 

3. Drug Development

Provides molecular-level information for the development of anti-skin aging and skin disease treatment drugs.

 

4. Beauty Skincare Product Evaluation

Analyze the impact of skincare products on skin glycation, evaluate its efficacy.

 

Services at MtoZ Biolabs

1. Sample Processing

Extract, purify, and pre-treat different types of skin samples.

 

2. Mass Spectrometry Analysis

Use LC-MS/MS and NMR technology for qualitative and quantitative analysis.

 

3. Data Processing and Verification

Use advanced software for data processing to ensure the accuracy and reliability of the analysis results.

 

Detectable Sugars and Substances Related to Sugar Metabolic Pathways

MtoZ Biolabs combines carbohydrate and carbohydrate metabolism pathway related substance standards with carbohydrate and carbohydrate metabolism pathway related substance isotope standards to perform quantitative and qualitative analysis of a variety of carbohydrate substances:

 

1. Low Molecular Weight Sugar Substances

Ribose, xylose, allose, maltose, arabinose, rhamnose, hydroxyethyl cellulose, fucose, glucose, mannose, galactose, fructose, maltose, lactose, cellulobiose.

 

2. Substances Related to Glycolysis / Tricarboxylic Acid Cycle / Nucleotide (Central Metabolic Pathway)

Acetyl coenzyme A, citrate/iso-citrate, butyrate, malate, 2-phosphoglycerate, phosphoenolpyruvate, AMP, ADP, ATP, FAD, NAD+, NADH, NADP+, NADPH, aldose-4-phosphate, ribose-5-phosphate, 6-phosphogluconate, heptose-7-phosphate, fructose-6-phosphate, fructose-1,6-bisphosphate.

 

MtoZ Biolabs provides reliable, fast and economically efficient metabolite analysis services based on a highly stable, repeatable and highly sensitive separation, characterization, identification and quantitative analysis system. MtoZ Biolabs looks forward to working with you, welcome to consult at any time, get more details!