Why Use Tumor Tissue and Adjacent Non-Tumor Tissue for Sequencing
In tumor research, it is common practice to collect both tumor tissue and adjacent non-tumor tissue for sequencing. The primary reasons are as follows:
1. Comparative Analysis
By comparing the genomic sequences of tumor tissue with those of adjacent non-tumor tissue, researchers can more accurately identify tumor-specific genetic alterations. Adjacent non-tumor tissue serves as a relatively normal reference, facilitating the identification of mutations that are directly implicated in tumor initiation and progression.
2. Baseline Establishment
Sequencing data from adjacent non-tumor tissue provide a baseline that helps researchers detect early-occurring genetic changes potentially driving tumorigenesis. Additionally, such data aid in characterizing the individual's germline genetic background, which contributes to a better understanding of tumor development.
3. Tumor Microenvironment Study
As an integral part of the tumor microenvironment, adjacent non-tumor tissue may influence tumor growth, invasion, and metastasis. Investigating this tissue offers insights into the dynamic interactions between the tumor and its surrounding microenvironment.
4. Prediction and Monitoring
In some cases, tumor-associated genetic alterations can also be detected in adjacent non-tumor tissue, possibly indicating early dissemination or minimal residual disease. This information is of significant clinical relevance for predicting disease progression, evaluating therapeutic responses, and monitoring for recurrence.
MtoZ Biolabs, an integrated chromatography and mass spectrometry (MS) services provider.
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