Which Three Amino Acids Are Involved in Protein Glycosylation Sites?
Protein glycosylation can be categorized into two main types: N-glycosylation and O-glycosylation.
N-Glycosylation
N-glycosylation occurs at the amide side chain of asparagine (Asn, N). N-glycosylation sites typically follow a specific sequence motif: Asn-X-Ser/Thr, where X can be any amino acid except proline due to structural constraints.
O-Glycosylation
O-glycosylation typically occurs on serine (Ser, S) or threonine (Thr, T). Unlike N-glycosylation, O-glycosylation does not exhibit strict sequence dependence.
Therefore, the three amino acids most commonly involved in protein glycosylation are asparagine, serine, and threonine.
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