Where to Find the Amino Acid Sequence of SUMO
"SUMO" (Small Ubiquitin-like Modifier) refers to a family of proteins that covalently attach to target proteins, thereby modulating their stability, subcellular localization, or biological function. SUMOylation represents a critical form of post-translational modification.
The amino acid sequence of SUMO can be obtained through the following commonly used online bioinformatics databases:
1. UniProt (Universal Protein Resource)
UniProt is a comprehensive and widely utilized resource for protein sequences and functional annotations. To retrieve a SUMO sequence, one can search the term “SUMO” via the database’s official website and select the appropriate organism from the search results to access the corresponding amino acid sequence.
2. NCBI Protein Database (National Center for Biotechnology Information)
This database also enables users to retrieve protein sequences by searching specific protein names. By entering “SUMO” into the search interface and selecting the desired entry, the full amino acid sequence can be accessed.
3. Protein Data Bank (PDB)
The PDB is a repository of three-dimensional structural data for proteins. If the structural information of SUMO is also of interest, searching for “SUMO” in this database can provide relevant 3D conformational data.
Importantly, “SUMO” denotes a family comprising distinct members such as SUMO1, SUMO2, and SUMO3, each possessing unique amino acid sequences. Therefore, it is essential to determine the specific SUMO isoform of interest prior to sequence retrieval.
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