What Mass Spectrometer is Generally Used for Peptide Identification
Q-TOF is a frequently used instrument for peptide identification due to its high resolution and precise mass measurement capabilities. The most commonly employed mass spectrometers for peptide identification include:
1. Orbitrap Series (e.g., Orbitrap Fusion Lumos)
These instruments offer high resolution and excellent mass accuracy, making them well-suited for the in-depth analysis of complex biological samples.
2. Q-TOF (Quadrupole-Time of Flight Mass Spectrometer)
This type of spectrometer combines the mass filtering capability of a quadrupole with the high resolution of a time-of-flight analyzer, enabling accurate mass determination and effective analysis of complex sample mixtures.
3. Triple Quadrupole Mass Spectrometer
Primarily utilized for quantitative analysis, this instrument delivers high sensitivity and specificity through multiple reaction monitoring (MRM).
Each of these instruments offers distinct advantages. The optimal choice depends on the specific experimental goals, such as sample complexity, the required mass resolution, and whether quantitative analysis is necessary.
MtoZ Biolabs, an integrated chromatography and mass spectrometry (MS) services provider.
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