What Are the Roles of Acetylation?
The primary roles of acetylation include:
Regulation of Gene Expression
Histone acetylation modulates chromatin structure, thereby regulating the accessibility of transcription factors and influencing gene expression.
Protein Function and Stability
Acetylation modulates protein conformation, impacting enzymatic activity, molecular interactions, and stability.
Cellular Signaling Pathways
Acetylation is involved in various signaling pathways, including apoptosis, cell cycle regulation, and metabolic control, playing a crucial role in cellular growth, differentiation, and survival.
Tumorigenesis and Cancer Progression
Dysregulated acetylation can contribute to tumorigenesis and cancer progression, making it a potential therapeutic target.
Moreover, acetylation is implicated in the pathogenesis of numerous diseases and remains a major focus of current biomedical research.
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