Terahertz Spectroscopy (THz) Analytical Service
- Targets: Pharmaceutical polymorphs, crystallinity, protein secondary structure changes.
- Typical Applications: Used for polymorphism analysis, distinguishing different crystalline forms and evaluating stability.
- Advantages: High signal-to-noise ratio, provides both time- and frequency-domain data, ideal for pharmaceutical quality control and molecular dynamics studies.
- Targets: Active pharmaceutical ingredients, complex formulations, excipient systems.
- Typical Applications: Analyzing drug and excipient composition for molecular fingerprint identification of complex mixtures.
- Advantages: High frequency resolution, capable of revealing molecular vibrational and energy transition characteristics.
- Targets: Liquid samples, highly absorbing materials.
- Typical Applications: Investigating molecular interactions in solution, especially for samples unsuitable for transmission measurements.
- Advantages: Minimizes strong absorption effects and enhances detection reliability for challenging sample types.
- Targets: Tablets, capsules, polymeric materials.
- Typical Applications: Internal composition mapping of tablets, coating thickness uniformity assessment, defect detection in dosage forms.
- Advantages: Combines spectral and spatial information to achieve 2D/3D imaging, enabling non-destructive visualization of drug structure and content distribution.
- Targets: Low-concentration active ingredients, biomolecules, trace impurities.
- Typical Applications: Suitable for trace-level analysis, detecting degradation products or impurity components.
- Advantages: Uses metamaterial structures to amplify electromagnetic interactions, significantly enhancing sensitivity and expanding the application range of THz spectroscopy.
Terahertz spectroscopy (THz) is an advanced analytical method based on electromagnetic waves in the 0.1–10 THz frequency range. This band lies between microwaves and infrared, combining some of the characteristics of both. It can penetrate non-conductive materials and provides unique molecular fingerprint recognition. THz spectroscopy primarily works by measuring the absorption and refraction characteristics of materials toward terahertz waves to obtain their distinctive spectral fingerprints. It is capable of characterizing molecular vibrations, rotations, and hydrogen-bond interactions, thereby offering valuable insights into the structure, composition, and physical state of substances. In pharmaceutical analysis, these features are essential for polymorphism studies, impurity detection, quality control, and stability evaluation.
With a well-established analytical platform and a professional team, MtoZ Biolabs offers terahertz spectroscopy (THz) analytical service to pharmaceutical companies, biotechnology enterprises, and research institutes, delivering high-quality and systematic THz-based solutions that support both fundamental research and applied development.
Services at MtoZ Biolabs
MtoZ Biolabs provides a comprehensive terahertz spectroscopy (THz) analytical service, covering the following main categories:
1. Terahertz Time-Domain Spectroscopy (THz-TDS)
2. Terahertz Frequency-Domain Spectroscopy (THz-FDS)
3. Terahertz Attenuated Total Reflection (THz-ATR)
4. Terahertz Imaging (THz Imaging)
5. Metamaterial-Enhanced Terahertz Spectroscopy
Analysis Workflow
1. Sample Reception and Requirement Confirmation: Confirm analysis type and target parameters based on client needs.
2. Sample Preparation: Ensure sample stability; may include grinding, film formation, or fixation if necessary.
3. THz Spectral Acquisition: Select appropriate mode (TDS, FDS, or Imaging) for data collection.
4. Data Processing and Interpretation: Baseline correction, noise reduction, peak extraction, and qualitative analysis.
5. Result Generation and Reporting: Deliver spectral data, interpretations, and application recommendations.
Service Advantages
1. Comprehensive Coverage of Multiple Detection Modes
MtoZ Biolabs’ terahertz spectroscopy (THz) analytical service includes THz-TDS, THz-FDS, THz-ATR, THz imaging, and metamaterial-enhanced THz modes, allowing flexible selection based on sample characteristics and research objectives. By combining these methods, we can simultaneously address analyses such as drug polymorphism, molecular structure, impurity detection, and formulation imaging, providing clients with systematic solutions.
2. High Sensitivity and High Resolution
With advanced spectral acquisition systems and optimized experimental workflows, we achieve high signal-to-noise ratios and resolution, ensuring data accuracy and reliability. The introduction of metamaterial-enhanced THz technology enables the detection of trace active ingredients and impurities, significantly extending the application range of THz spectroscopy to low-concentration analyses.
3. Non-Destructive and Label-Free Detection
THz spectroscopy employs non-ionizing radiation, which does not alter the physicochemical properties of the sample, making it suitable for specimens that require further experiments or storage. No additional labels or dyes are needed during measurement, ensuring the characterization of samples in their true state. This is particularly advantageous for non-destructive analysis of pharmaceutical tablets, proteins, and polymers.
4. Multi-Dimensional Data Output and Interpretation
Our terahertz spectroscopy (THz) analytical service provides not only raw spectral data but also time- and frequency-domain information, 2D/3D imaging results, and fingerprint peak analysis. With professional baseline correction, noise reduction, and feature extraction, clients receive clear and intuitive data interpretation along with application suggestions, supporting both research studies and industrial decision-making.
5. Professional Team and Customized Support
MtoZ Biolabs has a highly experienced analytical team that can design tailored testing strategies based on clients’ research questions and application requirements. From sample preparation to result interpretation, we provide full-process technical support. When needed, we also offer additional statistical analysis, methodological recommendations, and follow-up services, ensuring maximum value from the test results for both research and application.
Applications
1️⃣Pharmaceutical Analysis: Polymorphism studies, coating uniformity evaluation, stability testing.
2️⃣Biomedical Research: Protein conformation studies, biomolecular interaction analysis.
3️⃣Formulation Quality Control: Excipient characterization, capsule and tablet integrity assessment.
4️⃣Security Testing: Rapid identification of illicit and controlled substances.
5️⃣Materials Science: Characterization of excipients, polymers, and composite materials.
FAQs
1. How does THz spectroscopy differ from infrared or Raman?
THz spectroscopy is particularly suited for studying weak intermolecular interactions and crystalline structures, providing complementary insights to infrared and Raman.
2. How long does an terahertz spectroscopy (THz) analytical service take?
Typically, 1–2 days from sample preparation to data collection, depending on sample quantity and analysis type.
Sample Submission Suggestions
1. Sample Types: Powders, tablets, capsules, solutions, proteins, polymers, tissue slices, etc.
2. Sample Quantity: About 100 mg or 1–2 tablets per sample type for routine analysis.
3. Storage and Shipping: Store in a dry, light-protected environment; ship under ambient or dry ice conditions depending on stability.
Deliverables
1. Raw THz spectral data (time-domain/frequency-domain/imaging)
2. Spectral plots with fingerprint peak identification
3. Processed and statistically analyzed results
4. Professional analytical report (including conclusions and recommendations)
5. Optional customized follow-up support
As an emerging and efficient analytical method, terahertz spectroscopy is expanding rapidly into pharmaceuticals, life sciences, and related fields. Leveraging advanced instrumentation and a dedicated scientific team, MtoZ Biolabs provides a systematic terahertz spectroscopy (THz) analytical service.
If you are seeking a reliable partner for high-quality spectral analysis, MtoZ Biolabs is ready to deliver robust solutions tailored to your research and industrial projects.
How to order?
