T-IS Analysis Service
- Discovering new disease biomarkers
- Enhancing disease diagnosis
- Speeding up the discovery of innovative therapeutics
- Uncovering new insights into disease mechanisms
- Animal tissue ≥ 100 mg
- Plant tissue ≥ 200 mg
- Serum/ Plasma ≥ 200 μL
- Urine ≥ 2 mL
T-IS (Total Indoxyl Sulfate) is a compound containing an indole group and a sulfate ester group, with a chemical structure comprising an aromatic ring attached to a sulfate group. This compound is primarily produced through the metabolism of tryptophan by gut microbiota, followed by sulfation in the liver. Indoxyl sulfate exhibits biological activity, particularly in patients with chronic kidney disease, where it acts as a uremic toxin, exacerbating kidney damage.
Its metabolites include indole and indole-3-acetic acid, which play important roles in plant and microbial metabolism. Analyzing the levels of T-IS and its metabolites in plant and biological samples helps to understand the interactions between gut microbiota and host metabolism, and to reveal risks of kidney damage or other metabolic disorders. In plants, measuring indole-based metabolites is also significant for studying plant stress resistance and growth regulation.
Services at MtoZ Biolabs
MtoZ Biolabs, an integrated chromatography and mass spectrometry (MS) services provider, provides advanced metabolomics, proteomics and biopharmaceutical analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. Our ultimate aim is to provide more rapid, high-throughput, and cost-effective analysis, with exceptional data quality and minimal sample consumption. MtoZ Biolabs utilizes an LC-MS-based metabolomics research platform for the analysis of T-IS. We ensure the accuracy of the quantification of T-IS and its metabolites, as well as the comprehensiveness and precision of metabolite identification. If you are interested in our T-IS analysis service, please feel free to contact us at any time, and we will be fully committed to providing you with high-quality analytical services and technical support.
Analysis Workflow
Service Advantages
1. Advance Analysis Platform: MtoZ Biolabs established an advanced T-IS analysis platform, guaranteeing reliable, fast, and highly accurate analysis service.
2. One-Time-Charge: Our pricing is transparent, no hidden fees or additional costs.
3. High-Data-Quality: Extensive data coverage with rigorous quality control. Our advanced analysis platform consolidates all T-IS analysis data, delivering clients a detailed and comprehensive data report.
4. Quick Turnaround: We offer a fast analysis process to ensure that clients receive high-quality data within a short time.
Applications
Sample Submission Requirements
1. Sample Types
Serum, plasma, urine, tissues and other biological samples. It is necessary to select more than 3 materials with the same condition for each sample.
2. Sample Volume
3. Sample Preservation
Store at -80°C to maintain stability.
Note: Provide details on sample collection and handling.
Deliverables
1. Experimental Procedures
2. Relevant Liquid Chromatography and Mass Spectrometry Parameters
3. Detailed Information on T-IS Analysis
4. Raw Data
5. Custom Analysis Report
Through our T-IS analysis service, we aim to facilitate your research and product development processes by providing accurate and reliable results.
How to order?
