Resources
Proteomics Databases
Metabolomics Databases
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Spatial Seq is an innovative technique designed to acquire genomic information while preserving the spatial context of tissue sections. Unlike traditional sequencing methods, which require the dissociation of tissues or cells and result in the loss of spatial information, Spatial Seq enables high-resolution mapping of gene expression within intact tissues. This integration of spatial and genomic data allows researchers to investigate cellular behaviors and interactions within their native microenviron......
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• Single-Particle Cryo-Electron Microscopy
Single-Particle Cryo-Electron Microscopy is a cutting-edge high-resolution technique for visualizing the structures of biological macromolecules. Unlike traditional electron microscopy, which relies on staining or fixation and often introduces artifacts or sample deformation, this method employs rapid freezing at liquid nitrogen temperatures (approximately -196°C) to preserve samples in their native states. Its key advantage lies in achieving high-resolution structures without requiring sample crystal......
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Spatial RNA-Seq is a cutting-edge technology that enables the precise analysis of gene expression within the spatial framework of tissue sections. By integrating RNA sequencing with spatial information, it generates localized gene expression profiles, shedding light on the roles and interactions of cells within their native microenvironments. Unlike traditional RNA sequencing, which provides genome-wide data but lacks spatial resolution, spatial RNA-Seq not only identifies the transcriptional characte......
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HTS screening assays represent a powerful methodology for rapidly and efficiently evaluating the biological activities or properties of a vast number of compounds or biological samples. By integrating automation, miniaturization, and parallelization into experimental workflows, HTS screening assays enable the analysis of tens of thousands of samples in a short time frame. This approach has become indispensable in drug discovery, functional genomics, proteomics, and other domains of life sciences. In......
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• Single-Crystal X-Ray Crystallography
Single-Crystal X-Ray Crystallography is a powerful analytical method for determining the atomic and molecular structures of substances by analyzing X-ray diffraction patterns generated by single crystals. When X-rays interact with the periodic atomic lattice within a crystal, they produce a diffraction pattern that can be used to reconstruct the three-dimensional arrangement of atoms. This technique has wide-ranging applications across chemistry, physics, and biology and serves as a cornerstone for st......
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High-throughput assay refers to a rapid and highly efficient experimental approach designed to handle large-scale sample sets or datasets. Widely applied in disciplines such as biomedicine, drug development, genomics, and proteomics, this method leverages automation and integration to significantly enhance the speed and precision of data acquisition, thereby accelerating both fundamental research and clinical applications. In proteomics, high-throughput assay is indispensable as it facilitates the s......
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High-throughput screening (HTS) is a pivotal technology in modern biology, chemistry, and drug discovery. By integrating automation, miniaturization, and computational analysis, high-throughput screening enables the efficient and systematic screening of extensive sample or compound libraries to identify bioactive molecules, protein targets, or potential drug candidates. Its defining characteristics-speed and high throughput-allow for the rapid analysis of hundreds of thousands, or even millions, of sa......
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Single-cell ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing) is a cutting-edge technique for analyzing chromatin accessibility, providing insights into genomic regions that are available for binding by transcription factors and regulatory proteins. This method is an essential tool for elucidating genomic regulatory mechanisms, as chromatin accessibility plays a pivotal role in gene expression regulation by determining the availability of promoters, enhancers, and other regulatory......
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Spatial mass spectrometry is a cutting-edge analytical method that integrates mass spectrometry with spatial information acquisition, offering a multidimensional approach to molecular analysis in complex biological samples. Unlike traditional mass spectrometry, which focuses on overall sample composition, spatial mass spectrometry provides detailed molecular spatial distribution data, enabling the localization and detection of metabolites, lipids, proteins, and drugs within tissue samples. This tech......
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DART mass spectrometry (Direct Analysis in Real Time mass spectrometry) is an advanced analytical technique that offers rapid, non-destructive sample analysis without requiring extensive preparation. Unlike conventional mass spectrometry, DART mass spectrometry enables real-time examination of solids, liquids, and gases without solvent interaction, significantly enhancing analytical efficiency. Its key innovation is the ability to perform "real-time analysis," where molecular information is directly c......
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