Resources
Proteomics Databases
Metabolomics Databases
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• High Throughput Screening (HTS) Significance in Drug Discovery
The high throughput screening (HTS) significance in drug discovery cannot be overstated, as it is integral to the identification and optimization of potential drug candidates. Before the successful development of a new drug, it typically must emerge from an initial pool of millions of candidate molecules. This process resembles isolating a single pearl from the depths of an ocean. One of the pivotal technologies enabling this formidable task is high throughput screening (HTS). As the foundational step......
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• High Throughput Compound Screening
High throughput compound screening is a pivotal technology designed for the rapid evaluation and identification of biologically active compounds from large-scale chemical libraries. This technique enables the screening of thousands to millions of compounds within a short time frame, making it indispensable in the early stages of drug discovery. Pharmaceutical companies and research institutions leverage this approach to systematically examine vast compound collections, aiming to identify chemical enti......
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• Drug Discovery High Throughput Screening
Drug discovery high throughput screening is a cornerstone technology in modern pharmaceutical research. It enables the systematic and rapid evaluation of thousands to millions of small molecules, biomolecules, or natural products for potential biological activity using automated platforms and large-scale experimental systems. By integrating robotics, micro-volume liquid handling, multiplexed detection systems, and data analytics, drug discovery high throughput screening significantly enhances the effi......
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• Mass Spectrometry High Throughput Screening
Mass spectrometry high throughput screening is an analytical approach that leverages mass spectrometry to rapidly identify and quantify compounds within complex biological matrices, without the need for prior separation. This technique plays a crucial role in enabling precise, high-throughput molecular analysis directly from biological samples. In the pharmaceutical industry, it is frequently employed to screen thousands of candidate compounds to identify those with potential therapeutic efficacy. B......
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Mass spectrometry (MS) is an analytical technique used to determine the molecular mass and structural characteristics of compounds within a sample. By analyzing the mass-to-charge ratio (m/z) and relative abundance of ionized molecules, mass spectrometry (MS) enables the identification of diverse compounds, quantitative assessment of sample components, and elucidation of molecular structures. This technique is widely applied across multiple disciplines, including chemistry, biology, pharmaceutical dev......
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• Full Name of MS/MS (Tandem Mass Spectrometry)
MS/MS (Tandem Mass Spectrometry), also referred to as MS2, is a powerful analytical technique widely used for structural elucidation of molecules. In this method, molecules are first ionized and separated based on their mass-to-charge ratio (m/z) in the first stage of mass spectrometry (MS1). Selected precursor ions are then further fragmented in a second mass spectrometry stage (MS2 or MS/MS), enabling detailed structural analysis of the original compound. The core workflow of MS/MS (Tandem Mass Sp......
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Host cell DNA analysis refers to the detection and evaluation of DNA present in host cells using a variety of analytical techniques. This process is of critical importance in the biopharmaceutical industry, as host cells typically refer to cell lines used in the production of biologics, such as CHO cells and E. coli. During the manufacturing process, residual DNA fragments from these cell lines may remain in the final product. If not effectively detected and removed, these contaminants can compromise ......
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PROTAC drug discovery represents an innovative approach to therapeutic development that leverages the technology of proteolysis-targeting chimeras (PROTACs) to achieve targeted protein degradation. A PROTAC molecule typically consists of two functional ligands: one specifically binds to the target protein, while the other recruits an E3 ubiquitin ligase. These ligands are connected via an appropriate linker, forming a bifunctional molecule that facilitates ubiquitination and subsequent proteasomal deg......
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10x BCR sequencing is an advanced genomic technology specifically designed to investigate the complexity and dynamic changes of B cell receptors (BCRs). BCRs are essential components of the human immune system, responsible for recognizing and binding to foreign antigens, thereby initiating immune responses. By leveraging 10x BCR sequencing, researchers can gain in-depth insights into the processes of BCR gene recombination and somatic hypermutation, revealing how individual immune systems adapt to and......
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• De Novo Transcriptome Analysis
De novo transcriptome analysis is a powerful approach for comprehensively profiling the transcriptome of organisms, particularly those lacking fully sequenced or annotated genomes. This technique enables researchers to capture the full spectrum of RNA molecules expressed under specific conditions, facilitating the elucidation of complex gene expression patterns and regulatory networks. One of the key applications of de novo transcriptome analysis lies in gene discovery and functional annotation in n......
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