Resources

Proteomics Databases



Metabolomics Databases

• • Detection of Ubiquitinated Proteins by Nano-LC-MS/MS

  Ubiquitination is a key post-translational modification that regulates various cellular processes, such as protein degradation, activation, and subcellular localization, by covalently attaching the small protein ubiquitin to target proteins. Investigating the mechanisms of ubiquitination and identifying ubiquitinated proteins is crucial for understanding the pathogenesis of numerous diseases, including cancer and neurodegenerative disorders.

• • Detection of Protein Oxidative Modifications Based on Orbitrap Fusion Lumos Mass Spectrometry

  Protein oxidative modifications (OM) refer to the chemical modifications of protein amino acid residues induced by reactive oxygen species (ROS) and other reactive molecules under oxidative stress conditions. These modifications play significant roles in various biological processes, such as cell signaling, inflammation, and aging. Detecting protein oxidative modifications is crucial for understanding their functions in pathological and physiological processes.

• • Detection of Protein Modifications by Top-Down Proteomics

  Protein modification is a vital regulatory mechanism of protein function and activity within organisms. Post-translational modifications (PTMs), such as phosphorylation, acetylation, methylation, and ubiquitination, allow precise control over protein functions. These modifications not only play crucial roles in cellular signaling, metabolic regulation, and disease development, but also open new avenues for drug discovery and biomarker identification.

• • Quantitative Analysis of Protein Oxidative Modifications Using Mass Spectrometry

  Protein oxidative modifications are a common form of post-translational modification, playing crucial roles in regulating protein function, cellular signaling, and the pathogenesis of various diseases. Therefore, understanding and quantifying protein oxidative modifications are key to elucidating the mechanisms of redox balance in cells and their implications for disease.

• • MS Analysis of Unknown Protein Identification

  Mass spectrometry (MS) serves as a highly sensitive and high-resolution analytical technique, playing a crucial role in the identification of unknown proteins.

• • Analytical Techniques for Unknown Protein Identification

  The identification of unknown proteins is crucial in modern biological research. With advancements in genomics and proteomics, a vast amount of protein sequence data is available, yet understanding these proteins' functions remains challenging. This paper explores major analytical techniques used in protein identification, including mass spectrometry, X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and bioinformatics methods, highlighting their advantages and limitations.

• • Workflow of Quantitative Tyrosine Phosphoproteomics Analysis

  Protein phosphorylation is a critical modification in cellular signaling, metabolic regulation, and other biological processes. Tyrosine phosphorylation, in particular, plays a significant role in various biological contexts, including cell growth, differentiation, and cancer. Quantitative tyrosine phosphorylation proteomics is a powerful technique for comprehensively studying the levels and dynamics of tyrosine phosphorylation.

• • 4D DIA Proteomics: Comprehensive Overview of Protein Quantification and Differential Analysis

  Introduction Proteomics is the scientific field that studies the composition, structure, and function of all proteins in an organism. With the continuous development of technology, quantitative and differential analysis of proteomics has become an important research direction in the field of biopharmaceuticals.

• • 4D-DIA Label-Free Quantitative Proteomics: the Key Technology in Proteomics

  Proteomics is the discipline that studies the composition, structure, function, and interactions of all proteins in an organism. In recent years, with advancements in technology and continuous innovation in methods, the field of proteomics has made significant progress. Among them, 4D-DIA non-targeted quantitative proteomics, as a key technology, has been widely applied in the field of biopharmaceuticals.

• • Best Practice Sharing: How to Conduct Anti-Drug Antibody Testing

  Anti-Drug Antibody (Ada) refers to antibodies produced by the human immune system in response to exogenous drugs, such as biopharmaceuticals. These antibodies may impact the efficacy and safety of the drugs, making it crucial to detect and monitor the presence of Anti-Drug Antibodies (Ada).