Resources

Proteomics Databases



Metabolomics Databases

• • Chemical Proteomics Analysis Using the DARTS Method

  Chemical proteomics is a crucial technology for studying the interactions between small molecules and proteins. It provides key scientific insights for drug discovery, target validation, and biomarker research. Among various chemical proteomics approaches, DARTS (Drug Affinity Responsive Target Stability) is an efficient and label-free method widely used for exploring the interactions between compounds and protein targets.

• • Selection and Application of Molecular Weight Distribution Methods in Cross-Linking Mass Spectrometry

  In the field of biopharmaceuticals, accurate determination of the molecular weight is crucial to ensure the quality and stability of biologics. Chemical cross-linking mass spectrometry, as an important analytical technique, is widely used in the research and development of biologics. This article will delve into the selection and application of molecular weight distribution measurement methods in chemical cross-linking mass spectrometry, to help you understand the charm of this key technology.

• • High-Throughput Proteomics

  With the development of high-throughput proteomics technology, we are able to analyze the complexity and functionality of the proteome more quickly and comprehensively. This article will provide a detailed introduction to the concept and methods of high-throughput proteomics, with a focus on how this technology accelerates the analysis of proteome complexity and functionality, as well as its importance and application value in biomedical research.

• • How Does Flow Mass Spectrometry Analyze Metabolites in Complex Samples

  Research in the field of biopharmaceuticals requires in-depth analysis of the composition of metabolites in complex samples. Accurate analysis of metabolite composition is crucial for understanding the chemical processes within organisms, disease mechanisms, and drug development. In the past few decades, the rapid development of flow mass spectrometry technology has provided a powerful tool for metabolomics research.

• • Disulfide Bond Localization in Antibody Drugs

  Antibody drugs are a class of protein drugs produced through genetic engineering techniques, including monoclonal antibodies and antibody-drug conjugates. They have high specificity and can precisely target and neutralize disease-related molecules. In these antibody drugs, disulfide bonds are crucial for maintaining the three-dimensional structure and functional stability of the antibodies.

• • Detailed Workflow of Label-Free Proteomics Analysis

  Non-labeled proteomics analysis is an important technique used for studying protein composition and expression. Compared to labeled techniques, non-labeled proteomics analysis has advantages such as simplicity, high throughput, and high sensitivity.

• • NMR Hydrogen Spectrum Analysis of Conjugate Vaccine Carrier Proteins

  Combination vaccines, also known as conjugate vaccines, such as pneumococcal vaccines, belong to a special type of vaccine. The working principle of combination vaccines is to attach small molecule antigens (usually polysaccharides) to large molecule carrier proteins, which can typically stimulate strong immune responses.

• • Full Sequence Analysis of Recombinant Protein Vaccines by Mass Spectrometry

  Recombinant protein vaccines are vaccines prepared using genetic engineering techniques, with the aim of inducing an immune response by expressing and producing specific proteins of the pathogen. These vaccines do not contain the complete active pathogen, but instead select specific proteins or parts of proteins of the pathogen as antigens.

• • Mass Spectrometry Exploring Diverse Sites of Histone Epigenetic Modifications

  Epigenetic modifications are a genetic mechanism that alters gene expression without changing the genetic sequence. It mainly includes DNA methylation of the genome and modifications of histones. Among them, histone modifications are of particular interest in the field of biology and play a crucial role in the study of many major diseases.

• • Neoantigen Screening and Immunotherapy

  Cancer has always been a major threat to human health. However, with the continuous advancement of technology, immunotherapy, as an innovative cancer treatment, has gradually shown great potential. Immunotherapy activates the patient's own immune system to actively attack cancer cells, becoming the beacon of hope in leading the new era of cancer treatment. In personalized immunotherapy, the screening technology for neoantigens plays a crucial role.