Resources

Proteomics Databases



Metabolomics Databases

• • SEC-MALS Analysis

  SEC-MALS analysis is an advanced technique that combines Size Exclusion Chromatography (SEC) and Multi-Angle Light Scattering (MALS) to determine the absolute molecular weight, molecular size, and aggregation state of biomolecules. This method is widely employed in fields such as structural biology, proteomics, and biopharmaceuticals. The principle of SEC-MALS analysis involves separating sample components based on molecular size using SEC, followed by real-time analysis of the eluted fractions via an......

• • Proteomics Identify Differential Proteins

  Proteomics is a scientific approach focused on studying the protein composition and functionality within biological systems. Differential protein analysis is a key method for assessing variations in protein expression levels under different experimental conditions, such as comparing control and experimental groups. The following are standard methodologies for differential protein identification:

• • Protein Identification by Small Molecule Mass Spectrometry

  Protein small molecule identification using mass spectrometry is a technique employed to analyze and determine the composition and structure of proteins or peptides. This method primarily operates by measuring molecular mass and the mass-to-charge ratio (m/z), constituting a pivotal technology in proteomics research. The fundamental steps involved are as follows:

• • Quantitative Detection of Different Proteins Within a Cell

  Quantitative detection of different proteins within cells is a crucial aspect of biological and biomedical research. It aims to understand changes in protein expression levels, protein networks, and their roles in cell function and disease.

• • Spatial Proteomics Metal Tag

  Spatial Proteomics with Metal Tags is an advanced method that combines mass spectrometry and bioimaging technologies to study the spatial distribution and function of proteins at the tissue or cellular level. This technique involves labeling proteins with heavy metal ions, followed by imaging using Laser Ablation Mass Spectrometry Imaging (LA-MSI) or similar techniques. It enables precise analysis and visualization of protein distribution in biological tissues without damaging the samples.

• • Chemical Proteomics and Drug Target Discovery

  Chemical proteomics is a research approach that combines chemistry, biochemistry, and proteomics techniques. It is primarily used to study the interactions between proteins and small molecules, thereby revealing the functions and regulatory mechanisms of proteins, as well as their roles in diseases. The main steps include:

• • How to Identify Differences Between Two Groups of Proteins Through Proteomics Research

  The main steps involved in identifying differences between two groups of proteins through proteomics research include the following: Sample Preparation: Select two or more different conditions or sample groups (e.g., disease group and control group). Extract proteins and conduct necessary processing, such as protein concentration measurement and normalization. Protein Separation and Identification: Two-dimensional gel electrophoresis (2-DE) is a traditional protein separation technique that achieves......

• • Protein Chemistry and Proteomics

  Protein chemistry and proteomics are two important fields that study biomolecules, particularly proteins. They explore the structure, function, and interactions of proteins from different perspectives, providing a foundation for understanding biological processes and disease mechanisms. Although these fields are closely related, they differ in their focus and the technical methods they use.

• • Antibody-Drug Conjugate Analysis

  Antibody-Drug Conjugate Analysis refers to the process of in-depth study and evaluation of the structure, composition, and characteristics of antibody-drug conjugates (ADCs). ADCs represent a novel class of biotherapeutic agents that combine cytotoxic drugs with specific antibodies, enabling targeted delivery of the drug to cancer cells and achieving efficient tumor-killing effects. This strategy not only enhances the therapeutic index but also minimizes toxicity to healthy cells. The primary objectiv......

• • Antibody Sequencing Service for Drug Development

  Antibody Sequencing Service refers to the process of determining the amino acid sequence of an antibody through high-precision mass spectrometry analysis and bioinformatics techniques. Antibodies are critical molecules of the immune system, playing an essential role in defending against pathogens by recognizing and binding to specific antigens. Antibody sequencing services have wide-ranging applications in the biopharmaceutical field, including but not limited to antibody drug development, antibody en......