Resources

Proteomics Databases



Metabolomics Databases

• • PTM Analysis by Mass Spectrometry

  PTM analysis by mass spectrometry is a powerful technique in proteomics that provides detailed insights into the complex regulatory mechanisms of proteins. Post-translational modifications (PTMs) refer to covalent changes that occur after protein synthesis, such as phosphorylation, glycosylation, and acetylation. These modifications can profoundly influence protein function, stability, and cellular localization. Thanks to its high sensitivity, resolution, and throughput, mass spectrometry has become t......

• • Protein Target Identification

  Protein target identification is an essential step in proteomics research, aimed at identifying and validating proteins involved in specific biological processes, disease states, or drug interactions. Protein targets are those proteins that perform specific functions within and outside cells and may act as critical regulators in diseases or as direct drug targets. By elucidating the relationships between these proteins and their biological functions, scientists gain a deeper insight into cellular mech......

• • Proximate Analysis of Protein

  Proximate analysis of protein refers to the process in proteomics research that employs a range of bioinformatics and experimental techniques to compare and analyze similar protein sequences or structures, with the aim of uncovering their biological functions, evolutionary relationships, and structural characteristics. This approach involves evaluating sequence similarity, structural similarity, and functional similarity. Proximate analysis of protein is commonly used to predict the function of unknow......

• • Protein Structure Alignment and Analysis

  Protein structure alignment and analysis are crucial techniques in bioinformatics and structural biology. These techniques aim to elucidate evolutionary, functional, and sequence relationships by comparing the three-dimensional structures of proteins. Proteins, as complex molecules formed by folded amino acid chains, have their biological functions determined directly by their three-dimensional structures. Understanding these structures allows scientists to infer how proteins achieve their specific fu......

• • Protein Structure Identification: Methods and Challenges

  Protein structure identification refers to the determination of proteins' three-dimensional structures through experimental techniques to gain insights into their functional properties and biological roles. Proteins are pivotal in biological processes, acting as catalysts in enzymatic reactions or as receptors in signal transduction. Thus, understanding protein structures is vital for comprehending their functions. Structural identification not only elucidates how proteins interact with other molecule......

• • Monoclonal Antibody Analysis

  Monoclonal antibody analysis comprehensively evaluates the structure, function, and purity of monoclonal antibodies produced by a single B cell clone, known for their high specificity and consistency. This analysis plays a crucial role in ensuring antibody quality and functionality, supporting researchers and pharmaceutical companies in developing safe and effective antibody therapies. As a critical step in biomedicine's drug development process, the safety and efficacy of therapeutics heavily depend ......

• • HPLC Peptide Analysis

  HPLC peptide analysis is an effective technique for the separation and analysis of peptides within protein samples. This method uses a high-pressure liquid mobile phase passing through a column with a stationary phase to achieve component separation. It provides insights into protein molecular weights, amino acid sequences, and modification statuses, making it invaluable in proteomics. HPLC peptide analysis finds extensive use in biomedical research, drug development, and food safety testing. In biome......

• • LC-MS Peptide Analysis

  LC-MS peptide analysis is a pivotal analytical technique for investigating protein structures and functions. This method integrates the separation capability of liquid chromatography with the detection power of mass spectrometry, enabling precise identification and quantification of peptides in complex biological samples. By separating the sample's different compounds, liquid chromatography facilitates clear identification of each peptide's characteristics during subsequent mass spectrometry analysis.......

• • Antibody Protein Sequencing

  Antibody protein sequencing is a vital technique for determining the amino acid sequences of antibody molecules. As key components of the immune system, antibodies have structures and functions directly linked to their ability to identify and neutralize foreign pathogens. The diversity and specificity of antibodies are largely dictated by their amino acid sequences. Thus, obtaining detailed sequence information is crucial for advances in biomedical research, drug development, and immunological studies......

• • C-Terminal Sequencing of Proteins

  C-terminal sequencing of proteins involves identifying and analyzing the amino acid sequence at the protein's carboxyl-terminus using various chemical or enzymatic methods. In the field of proteomics, determining the C-terminal sequence is crucial as it influences the protein's function, stability, cellular localization, and interactions. Alterations in the C-terminal sequence can lead to various diseases, making it vital for diagnostic and therapeutic purposes. Moreover, C-terminal sequencing of prot......