PRM Based Quantitative Phosphoproteomics Analysis Service

Phosphorylation, a critical post-translational modification, is essential in regulating cellular signaling pathways and metabolic processes. Dysregulation of phosphorylation is implicated in the pathogenesis of metabolic disorders, cancer, and neurodegenerative diseases. As a result, phosphoproteomics plays a vital role in elucidating the underlying mechanisms of these conditions. However, the detection of phosphorylated peptides remains challenging due to their low abundance and dynamic nature.

 

MtoZ Biolabs offers PRM Based Quantitative Phosphoproteomics Analysis Service, utilizing the high-resolution Q-Orbitrap mass spectrometry platform. PRM enhances detection accuracy by selecting precursor ions via a quadrupole and conducting high-resolution full-scan analysis of all fragment ions, ensuring both quantitative and qualitative precision. Unlike traditional antibody-based methods, PRM provides significant advantages in analyzing low-abundance phosphorylated proteins, especially in complex biological matrices. This makes PRM particularly suited for applications in basic research, drug development, and disease mechanism investigations.

 

 

Figure 1. Schematic Diagram of the PRM

 

Analysis Workflow

 



 

Service Advantages

Why Choose MtoZ Biolabs?

1. Advance Analysis Platform: MtoZ Biolabs established an advanced protein PTM analysis platform, guaranteeing reliable, fast, and highly accurate analysis service.

2. One-Time-Charge: Our pricing is transparent, no hidden fees or additional costs.

3. High-Data-Quality: Deep data coverage with strict data quality control. AI-powered bioinformatics platform integrate PTM proteomics analysis data providing clients with a comprehensive data report.

4. Antibody-Independent Detection: PRM does not require antibodies, broadening its applicability in analyzing complex biological samples while avoiding the specificity limitations of antibody-based methods.

5. Wide Dynamic Range: PRM technology offers an expanded linear dynamic range, allowing for simultaneous detection of multiple phosphorylation targets, making it ideal for large-scale proteomics studies.

 

Sample Submission Requirements

 



 

Applications

1. Signal Transduction Research

Analyze key phosphorylation events to understand intracellular signaling pathways.

 

2. Disease Biomarker Research

Identify and quantify disease-related phosphorylated proteins to discover novel biomarkers.

 

3. Drug Target Validation

Evaluate the impact of therapeutic agents on phosphorylation pathways, aiding in drug development.

 

4. Personalized Medicine Research

Investigate phosphorylation patterns in patient samples to support personalized treatment strategies.

 

MtoZ Biolabs, an integrated Chromatography and Mass Spectrometry (MS) Services Provider, provides advanced proteomics, metabolomics, and biopharmaceutical analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. Our ultimate aim is to provide more rapid, high-throughput, and cost-effective analysis, with exceptional data quality and minimal sample consumption. Free project evaluation, welcome to learn more details!