Pan-3D Genomics Analysis Service
- Investigate the relationship between genomic structural variations and complex diseases (e.g., cancer, neurological disorders) to uncover potential pathogenic mechanisms.
- Explore dynamic changes in the 3D genome during cell differentiation and development to understand the spatial mechanisms of developmental regulation.
- Analyze spatial interactions between genes and distal regulatory elements to reveal the higher-order structure of gene regulatory networks.
- Combine epigenetic modifications with 3D genomic structure to elucidate their roles in gene expression regulation.
Pan-3D genomics is a cutting-edge field that explores the spatial organization and functional dynamics of the genome through three-dimensional structural information. While traditional genomics focuses primarily on one-dimensional DNA sequences, pan-3D genomics extends beyond linear sequences, examining the three-dimensional spatial arrangement of genes and how higher-order genome organization influences gene regulation and expression. This integration of three-dimensional data offers new insights into genome functionality, particularly in complex biological processes such as cell differentiation, development, and disease progression.
By employing advanced high-throughput chromatin conformation capture techniques (such as Hi-C), chromatin immunoprecipitation sequencing (ChIP-seq), and other omics technologies, pan-3D genomics enables the analysis of chromatin interactions and spatial architecture, uncovering connections between genes and distant regulatory elements. MtoZ Biolabs offers comprehensive Pan-3D Genomics Analysis Service, leveraging state-of-the-art technology platforms to help researchers investigate the three-dimensional genome structure and its regulatory roles, facilitating breakthroughs in gene regulation and disease research.
Berkum, N. et al. J. Vis. Exp. 2010.
Figure 1. Hi-C Overview
Service Advantages
Why Choose MtoZ Biolabs?
1. Comprehensive 3D Genome Mapping: Leveraging Hi-C and related techniques, we generate complete maps of the genome's spatial architecture, revealing complex gene-regulatory interactions.
2. High Resolution and Precision: Our use of advanced sequencing platforms ensures high-resolution, accurate data, providing invaluable support for in-depth studies of gene regulation.
3. Multi-Omics Integration: Combining data from ChIP-seq, RNA-seq, and other omics platforms, we offer multi-dimensional analyses that uncover the full scope of gene expression regulation mechanisms.
4. Tailored Analysis Services: We provide customized pan-3D genomics analysis services tailored to clients' specific research goals, ensuring optimal outcomes for each project.
5. Rapid Turnaround: Our efficient workflows and data analysis processes enable quick delivery of high-quality results, supporting timely scientific progress.
Sample Submission Requirements
1. Sample Types
Cell or tissue samples, which must be properly fixed to maintain chromatin structure.
2. Sample Volume
A minimum of 5 to 10 million cells or 100-200 mg of tissue per sample is recommended.
3. Sample Preservation
Store samples at -20°C or lower to prevent degradation, avoiding repeated freeze-thaw cycles.
Applications
Application Case
Pan-3D genome analysis reveals structural and functional differentiation of soybean genomes
Ni, L. B. et al. Genome Biol. 2023.
Deliverables
What Could be Included in the Report?
1. Comprehensive Experimental details
2. Materials, Instruments, and Methods
3. Total Ion Chromatogram & Quality Control Assessment (project-dependent)
4. Data Analysis, Preprocessing, and Estimation (project-dependent)
5. Bioinformatics Analysis
6. Raw Data Files
MtoZ Biolabs is committed to offering cutting-edge solutions in Pan-3D Genomics, providing in-depth insights into the spatial and functional architecture of the genome. By integrating advanced technologies and delivering comprehensive data analyses, our services empower researchers to explore gene regulation, disease mechanisms, and developmental biology with precision. Through our professional and tailored service approach, we strive to support groundbreaking discoveries in the field of genomics.
How to order?
