O6-methylguanosine Analysis Service
- State-of-the-art LC-MS/MS platforms allow us to accurately and reliably quantify O6-methylguanosine in various types of samples.
- A team of experts in mass spectrometry and metabolomics provides professional data analysis and interpretation.
- One-stop service from sample preparation, LC-MS/MS analysis to data analysis, saving your time and efforts.
- Competitive price with high-quality service.
- Biomarker discovery for DNA damage and repair.
- Assessment of risk of mutagenesis and carcinogenesis.
- Evaluation of exposure to alkylating agents.
- Monitoring the effectiveness of anticancer therapies.
- Animal tissue ≥ 100 mg
- Plant tissue ≥ 200 mg
- Serum/ Plasma ≥ 200 μL
- Urine ≥ 2 mL
O6-methylguanosine is a DNA lesion caused by alkylation damage, which can be a result of both environmental factors and endogenous cellular processes. It is a methylated form of guanosine, a nucleoside consisting of guanine attached to a ribose ring. O6-methylguanosine has been recognized as a potent mutagenic lesion because it can mispair with thymine during DNA replication, leading to G:C to A:T transition mutations. It plays a key role in carcinogenesis, ageing, and other disease states. This has made its analysis an area of intense scientific and clinical interest.
The detection and quantitation of O6-methylguanosine can provide valuable information about the level of alkylating DNA damage and repair capacity in cells or tissues, as well as the potential for mutagenesis and carcinogenesis. It can also be used as a biomarker for exposure to alkylating agents, both endogenous and exogenous, and for the efficacy of anticancer therapies that target DNA alkylation damage.
Figure 1. The Structure of O6-methylguanosine
At MtoZ Biolabs, we use LC-MS/MS (Liquid Chromatography with tandem Mass Spectrometry), an advanced platform for the accurate and sensitive analysis of O6-methylguanosine. Our scientists are experts in metabolomics with a deep understanding of alkylation damage, DNA repair, and carcinogenesis.
Analysis Workflow
Service Advantages
Applications
Sample Submission Requirements
1. Sample Types
Serum, plasma, urine, tissues, and other biological samples. It is recommended to prepare at least 3 biological replicates for each sample type.
2. Sample Volume
3. Storage and Shipping
Samples should be stored at -80℃ and shipped with dry ice. Avoid repeated cycles of freezing and thawing
Note: Please provide details on sample collection and handling.
Deliverables
1. Experimental Procedures
2. Relevant Liquid Chromatography and Mass Spectrometry Parameters
3. Detailed Information on O6-methylguanosine
4. Raw Data
5. Custom Analysis Report
Trust in MtoZ Biolabs to provide you with reliable and insightful O6-methylguanosine analysis service. Contact us today to discuss your project needs.
How to order?
