Norcholic Acid Analysis Service

Norcholic acid (NCA) is a significant bile acid derivative, formed through the demethylation of cholic acid (CA) during metabolism. NCA plays a unique role in bile acid metabolism and cholesterol balance, with its levels potentially linked to various hepatobiliary and metabolic diseases. Given NCA's distinct metabolic pathways and its potential connections to several pathological states, accurate analysis of NCA concentrations and its metabolites is crucial for disease diagnosis and research

 

Figure 1. Molecular Structure of Norcholic Acid

 

MtoZ Biolabs offers Norcholic Acid Analysis Service using high performance liquid chromatography-mass spectrometry (HPLC-MS). This advanced method combines the separation capabilities of HPLC with the detection power of MS, ensuring high sensitivity and specificity in NCA detection.

 

Analysis Workflow

 



 

Service Advantages

• Rapid Analysis Cycle and Cost-Effectiveness
• Stable, Reliable, and Highly Sensitive Results
• Comprehensive One-Stop Service for Extensive Testing Needs
• User-Friendly Operation with Wide Application Scope
• Supported by Extensive Bioanalytical Resources and Advanced Platforms

 

Sample Submission Requirements

1. Sample Types

Serum, plasma, urine, feces, tissue extracts, and other biological samples.

 

2. Sample Volume

At least 200 μL of liquid sample or 200 mg of solid sample.

 

3. Sample Preservation

Store at -80°C to maintain stability.

 

Note: Provide details on sample collection and handling.

 

Applications

• Hepatobiliary Disease Research
• Bile Acid Metabolism Research
• Metabolic Disease Research
• Drug Development
• Toxicity Assessment

 

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on Norcholic Acid

4. Raw Data

5. Custom Analysis Report

 

MtoZ Biolabs is dedicated to advancing your research and clinical projects by providing detailed insights into NCA's extensive physiological roles through top-tier analytical techniques and expert services.