Nasopharyngeal Carcinoma Tissue MRM/PRM Quantitative Proteomic Analysis

Nasopharyngeal carcinoma is a malignant tumor originating from the epithelium of the nasopharynx, with significant geographic differences in incidence and mortality rates globally, especially common in Southeast Asia. Early diagnosis and treatment of nasopharyngeal carcinoma are crucial. However, due to the anatomical location of the nasopharynx, early symptoms are not evident, leading to late-stage disease detection. Therefore, developing efficient biomarker detection techniques is of great significance for the early diagnosis, treatment, and prognosis assessment of nasopharyngeal carcinoma.

 

Introduction to MRM/PRM Technology

MRM (Multiple Reaction Monitoring) and PRM (Parallel Reaction Monitoring) are proteomic analysis methods based on mass spectrometry, particularly suitable for quantitative analysis of specific proteins. MRM technology quantifies proteins by presetting the conversion from precursor ions to product ions, while PRM technology records all available product ion information, offering more comprehensive data.

 

The high sensitivity and repeatability of these technologies make them outstanding in clinical sample analysis, especially in the verification and quantitative analysis of protein markers.

 

Service Advantages

1. High Sensitivity

It can accurately detect low-abundance proteins in complex biological samples, which is particularly important for identifying early markers of nasopharyngeal carcinoma.

 

2. High Accuracy

Through precise mass filtering and quantitative analysis, MRM/PRM technology can provide very accurate protein quantification information.

 

3. High Repeatability

MRM/PRM technology demonstrates good repeatability in multiple experiments, which is particularly important for the clinical diagnosis and treatment effect evaluation of nasopharyngeal carcinoma.

 

4. Fast and High Throughput

This technology supports rapid analysis of multiple target proteins in multiple samples, suitable for large-scale clinical sample processing.

 

5. Wide Dynamic Range

It can detect proteins with a wide range of abundance differences, which is of great value in revealing the pathogenesis of nasopharyngeal carcinoma.

 

Application

1. Biomarker Discovery

Locate and quantify potential protein markers in nasopharyngeal carcinoma tissues for disease diagnosis and treatment response monitoring.

 

2. Disease Mechanism Research

Analyze the expression differences of proteins in nasopharyngeal carcinoma tissues to reveal the molecular mechanism of cancer development.

 

3. Treatment Effect Evaluation

Quantitatively analyze the changes in proteins in nasopharyngeal carcinoma tissues before and after treatment, assessing the treatment effect.

 

4. Drug Target Validation

Confirm the target of nasopharyngeal carcinoma treatment drugs, aiding drug development and individualized treatment.

 

The MRM/PRM quantitative proteomics analysis technology provides a powerful tool for the early diagnosis, disease monitoring, and treatment effect evaluation of nasopharyngeal carcinoma. As the application of this technology in nasopharyngeal carcinoma research deepens, it is expected to help doctors better understand disease mechanisms, optimize treatment plans, and ultimately improve patients' survival rates and quality of life.