Nanoparticle Tracking Analyzer (NTA) Analytical Service
- Advanced instrumentation with rigorous calibration procedures.
- Expertise in handling diverse nanoparticle types, from biological vesicles to synthetic carriers.
- Comprehensive data packages tailored to your research or development needs.
- Rapid turnaround times supported by streamlined workflows.
- Dedicated scientific support to interpret results and guide project decisions.
Nanoparticles are powerful tools in drug delivery systems, diagnostics, vaccines, and biomaterials. With increasing interest in extracellular vesicles such as exosomes, as well as synthetic nanocarriers like lipid nanoparticles (LNPs), accurate characterization of nanoparticle size distribution and concentration has become a critical requirement.
Techniques such as dynamic light scattering (DLS) and electron microscopy provide valuable insights but often face limitations when it comes to detection accuracy or real-time quantification. Nanoparticle tracking analyzer (NTA) has become a widely adopted tool because it combines video microscopy with Brownian motion tracking to provide robust and reproducible nanoparticle characterization. The nanoparticle tracking analyzer offers quantitative measurements of particle size and concentration that help researchers assess particle heterogeneity and sample quality in diverse contexts.
Technical Principles
Nanoparticle Tracking Analysis is based on the principle of tracking the Brownian motion of individual nanoparticles suspended in a liquid. When nanoparticles are illuminated by a laser beam, they scatter light that can be captured by a video microscope. The movement of each particle, driven by random collisions with solvent molecules, can be tracked frame by frame.
Urso M. et al. Nat Commun. 2022.
Figure 1. Scheme of the NTA Working Principle
Service at MtoZ Biolabs
MtoZ Biolabs provides a comprehensive Nanoparticle Tracking Analyzer (NTA) Analytical Service equipped with advanced fluorescence modules that enable selective monitoring of labeled particles, effectively reducing background interference and enhancing specificity for targeted populations. Building on this capability, our service portfolio delivers accurate, reproducible, and publication-ready results, including:
1. Particle Size Characterization
Determination of mean and median particle diameters with high-resolution distribution profiles to capture sample heterogeneity.
2. Concentration Measurement
Quantification of nanoparticle concentration expressed as particles per milliliter, enabling batch-to-batch quality assessment.
3. Brownian Motion Video Tracking
Recording and analysis of nanoparticle trajectories to visualize diffusion behavior and confirm particle dynamics in real time.
Urso M. et al. Nat Commun. 2022.
Figure 2. Frames of the Videos of Nanoplastics’ Suspensions after Serial Dilution
Sample Submission Suggestions
1. Sample Types
Exosomes, extracellular vesicles, lipid nanoparticles, virus-like particles, polymeric nanoparticles, protein-based carriers, and colloidal suspensions.
2. Volume Requirement
At least 2 mL per liquid sample is recommended.
Note: If you have special sample types or require additional guidance, please contact us for personalized support before sample preparation.
Service Advantages
MtoZ Biolabs is dedicated to providing reliable nanoparticle characterization services that empower researchers and developers. By choosing us, you benefit from:
Applications
Nanoparticle Tracking Analyzer (NTA) Analytical Service is highly versatile and applicable across a wide range of research and development areas:
1. Exosome and Extracellular Vesicle Research
Characterization of exosomes and microvesicles in biological fluids or cell culture supernatants. NTA supports biomarker discovery, cell communication studies, and diagnostic development.
2. Nanomedicine Development
Evaluation of lipid nanoparticles, polymeric micelles, and protein-based carriers for DNA, RNA, and small-molecule drug delivery. NTA provides crucial data on carrier uniformity and stability.
3. Vaccine Development
Characterization of virus-like particles (VLPs) and other vaccine carriers. Accurate size and concentration information aids in quality control and optimization of vaccine formulations.
4. Colloid and Nanomaterial Research
Measurement of engineered nanoparticles, emulsions, and colloidal suspensions for industrial or environmental studies.
5. Quality Control in Manufacturing
Ensuring batch-to-batch consistency in nanoparticle production for pharmaceutical and biotechnology companies.
If you are interested in our Nanoparticle Tracking Analyzer (NTA) Analytical Service, please feel free to contact us. Our technical specialists are available to provide a free business assessment.
How to order?
