N-Formylkynurenine Analysis Service

N-Formylkynurenine is a formylated derivative of kynurenine, an intermediate in the tryptophan catabolism pathway. Its structure consists of a kynurenine core with a formyl group attached to the amino group at the N-position. This compound is primarily known for its role as a precursor in the kynurenine pathway, the main route of tryptophan degradation in mammals. N-Formylkynurenine is formed from tryptophan by the action of the enzyme indoleamine 2,3-dioxygenase (IDO) or tryptophan 2,3-dioxygenase (TDO), both of which catalyze the initial and rate-limiting step in this pathway.

 

N-Formylkynurenine is commonly used in research to study the metabolism of tryptophan and its associated pathways, especially in relation to immune response and neurodegenerative diseases. Although N-formylkynurenine itself is not widely used as a therapeutic agent, understanding its formation and conversion can provide insight into the regulation of the immune system and the pathogenesis of diseases such as cancer, neurodegenerative disorders, and mood disorders. It is frequently measured in clinical studies to assess tryptophan metabolism rates, which is relevant in fields such as immunology and neurology.

 



Figure 1. The Structure of N-Formylkynurenine

 

MtoZ Biolabs is proud to present our state-of-the-art N-Formylkynurenine Analysis Service. Backed by our cutting-edge liquid chromatography-mass spectrometry (LC-MS) platform and our expert metabolomics team, we are committed to providing a comprehensive N-formylkynurenine analysis with high sensitivity and precision.

 

Analysis Workflow 

 



 

Service Advantages

1. Continuously refined protocols and cutting-edge analytical tools  

 

2. Expert experimental planning  

 

3. Rapid processing times  

 

4. Exceptional precision, selectivity, and sensitivity

 

Applications

• Qualitative analysis of the metabolites of N-formylkynurenine
• Quantitative analysis of N-formylkynurenine content
• Provide basis for pharmacological studies

 

Sample Submission Requirements

1. Sample Types

Serum, plasma, urine, tissues and other biological samples. It is necessary to select more than 3 materials with the same condition for each sample. 

 

2. Sample Volume

• Animal tissue ≥ 100 mg
• Plant tissue ≥ 200 mg
• Serum/ Plasma ≥ 200 μL
• Urine ≥ 2 mL

 

3. Sample Preservation

Ensure samples are stored at -80°C to maintain stability.

 

Note: Further information is required on sample collection and handling.

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on N-Formylkynurenine

4. Raw Data

5. Custom Analysis Report

 

Through our N-formylkynurenine analysis service, we aim to support your research and product development endeavors by offering accurate and reliable results.