Morphologically Directed Raman Spectroscopy (MDRS) Analysis Service
- Advanced instrumentation that integrates particle imaging with Raman spectroscopy.
- Customized workflows that adapt to your project's unique requirements.
- Rigorous quality control for reproducible and defensible data.
- Timely project delivery supported by efficient processes.
- Comprehensive support from our experienced scientific team.
The characterization of particles is a critical step in pharmaceutical development, material science, nanotechnology, and environmental research. Morphologically Directed Raman Spectroscopy (MDRS) combines automated imaging with Raman spectral profiling to provide a dual perspective on individual particles within complex samples. This integrated approach not only characterizes particles that display expected morphological features but also identifies unknown or atypical particles. MDRS has emerged as an essential tool for researchers and developers seeking detailed insights into particle populations in complex formulations and heterogeneous samples. MtoZ Biolabs provides professional Morphologically Directed Raman Spectroscopy (MDRS) Analysis Service to help clients obtain high-quality, reproducible data on both the shape and composition of particles.
Technical Principles
Morphologically Directed Raman Spectroscopy integrates two powerful analytical techniques: automated particle imaging and Raman spectroscopy.
1. Particle Imaging
Automated microscopy captures high-resolution images of thousands of individual particles within a sample. From these images, morphological parameters such as size distribution, circularity, aspect ratio, and surface texture are calculated.
2. Raman Spectroscopy
Raman spectroscopy relies on inelastic scattering of monochromatic light to generate a molecular fingerprint for each particle. The resulting Raman spectra provide detailed information about the chemical composition and molecular structure.
3. Integration of Morphology and Composition
By directing Raman spectroscopy to specific particles identified through imaging, MDRS enables simultaneous acquisition of morphological and chemical data. This combination allows direct correlation between particle shape and composition, offering insights that cannot be achieved with either technique alone.
Kim, M. et al. Sci Rep. 2023.
Figure 1. Characterization of Proteinaceous Particles Formed in Stressed mAb Samples using MDRS.
(A) (B) Representative particle images, (C) particle size distributions, (D)–(G) morphological data histograms,
(H) (I) representative Raman spectra of proteinaceous particles in stressed mAb samples measured by the MDRS system.
Service at MtoZ Biolabs
MtoZ Biolabs offers end-to-end MDRS analytical solutions tailored to diverse research and industrial needs. Our services include, but are not limited to:
1. Morphological Characterization
High-resolution particle imaging to determine size distribution, aspect ratio, circularity, and surface features.
2. Raman Spectral Analysis
Collection of Raman spectra to identify molecular composition and confirm material identity using reference libraries.
3. Integrated Morphology and Composition Correlation
Direct linkage of particle shape with chemical identity for detailed population analysis.
4. Targeted Particle Analysis
Ability to focus Raman analysis on specific particles of interest, such as rare contaminants or critical API populations.
5. Customizable Workflows
Flexible service options for pharmaceutical, nanotechnology, and environmental projects, ensuring solutions meet unique client requirements.
Service Advantages
MtoZ Biolabs is committed to delivering high-quality particle characterization services that empower scientific discovery and product development. By choosing our Morphologically Directed Raman Spectroscopy (MDRS) Analysis Service, you gain:
Sample Submission Suggestions
1. Sample Types
Powders, suspensions, emulsions, nanomaterials, drug formulations, excipients, and microplastics.
2. Sample Volume
Typically, 1 g for solid samples or 20 mL for liquid samples.
If you have special sample types or require additional guidance, please contact us for personalized support before sample preparation.
Applications
MDRS is highly versatile and supports a wide range of research and industrial applications. Key areas include:
1. Pharmaceutical Development
Morphologically Directed Raman Spectroscopy (MDRS) Analysis Service is invaluable for characterizing active pharmaceutical ingredient (API) particles, excipients, and complex formulations. It supports polymorph identification, detection of blends, and assessment of particle uniformity in inhalable drugs or oral dosage forms.
2. Polymorph and Crystal Form Analysis
Different crystal forms of the same compound can exhibit different solubility, stability, and bioavailability. MDRS allows discrimination of polymorphs by combining shape information with Raman-based chemical fingerprints.
3. Contaminant Identification
MDRS helps identify unknown particles or contaminants in drug products, raw materials, or production environments. The ability to determine both morphology and composition accelerates root-cause analysis and corrective actions.
4. Nanotechnology and Material Science
MDRS is useful for analyzing engineered nanomaterials, pigments, polymers, and composites. Researchers gain insights into particle populations and correlations between particle structure and performance.
5. Environmental and Biological Studies
Morphologically Directed Raman Spectroscopy (MDRS) Analysis Service can be applied to characterize microplastics, aerosols, or biological particles. The dual information supports environmental monitoring, toxicology, and biomedical research.
6. Quality Control and Regulatory Compliance
MDRS provides robust datasets for regulatory submissions, ensuring compliance with guidelines on particle characterization in pharmaceuticals and related industries.
MtoZ Biolabs delivers reliable MDRS analysis to help researchers and developers make confident decisions in product development, quality control, and scientific discovery. For more information about our Morphologically Directed Raman Spectroscopy (MDRS) Analysis Service, please contact us.
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