Mass Spec Protein Analysis Service

Mass spec protein analysis measures the mass-to-charge ratio of ions to identify and quantify protein by mass spectrometry. Mass spectrometry is a indispensable tool in efficient and precise analysis of protein in simple and complex samples. The continuous advancements in mass spectrometry have led to breakthroughs in accuracy, sensitivity, and throughput in proteomics, driving deeper progress in protein structure, function, post-translational modifications and interactions. In life science, mass spec protein analysis can be used to study molecular mechanisms, explore disease progression, and identify potential therapeutic targets. In drug development, it helps optimize candidate drug molecules, monitor the quality of biopharmaceuticals, and improve the success rate of drug development.

 

Service at MtoZ Biolabs

MtoZ Biolabs, an integrated chromatography and mass spectrometry (MS) services provider, provides advanced proteomics, metabolomics, and biopharmaceutical analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. As a leading biotechnology company with extensive experience in the protein field, our mass spec protein analysis service is highly advanced, backed by numerous practical cases and expertise in MS. We offer the following analysis services, but are not limited to:

1. Mass Spec Protein Identification

 



Dupree, EJ. et al. Proteomes. 2020.

Figure 1. Workflow of Mass Spec Protein Identification 

 

2. Mass Spec Protein Quantitation

 



Anand, S. et al. Methods Mol Biol. 2017.

Figure 2. Workflow of Mass Spec Protein Quantitation

 

3. Mass Spec Protein Sequencing

 



 de, Graaf, SC, et al. MAbs. 2022.

Figure 3. Workflow of Mass Spec Protein Sequencing

 

4. Mass Spec Protein PTM Analysis

 

 

 

Bobalova, J. et al. J Agric Food Chem. 2023.

Figure 4. Workflow of Mass Spec Protein PTM Analysis

 

5. Mass Spec Protein Structure Analysis

 



Takemori, Nobuaki. et al. Front. anal. sci. 2023.

Figure 5. Workflow of Mass Spec Protein Structure Analysis

 

6. Mass Spec Protein Interaction Analysis

 



Goel, RK. et al. Curr Opin Struct Biol. 2024. 

Figure 6. Workflow of Mass Spec Protein Interaction Analysis

 

Service Advantages

1. State-of-the-Art Instrumentation: Equipped with Thermo Fisher Orbitrap series, Q Exactive HF mass spectrometers, Nano-LC nanoscale liquid chromatography systems, our mass spec protein analysis service meets a wide range of needs from protein identification to post-translational modification analysis, delivering high-sensitivity and high-resolution results.

 

2. Fast Turnaround Time: MtoZ Biolabs optimizes experimental workflows and leverages efficient data processing capabilities to significantly reduce the delivery time of mass spectrometry protein analysis, providing timely support for research projects and accelerating scientific progress.

 

3. Extensive Analytical Expertise: With years of experience in mass spectrometry protein analysis, our team is proficient in handling and analyzing various sample types. We have successfully completed numerous complex and challenging projects, ensuring the accuracy and reliability of the results.

 

4. Customized Solutions: Tailored to the specific needs of our clients, we offer flexible service options, including in-depth analysis of specific targets, post-translational modification identification, and large-scale proteomics studies, fully meeting personalized experimental requirements.

 

Applications

1. Basic Research: Mass spec protein analysis can be used for protein identification, post-translational modification analysis (e.g., phosphorylation, glycosylation), and studying protein interaction networks, aiding in the understanding of molecular mechanisms of life processes.

 

2. Disease Research: In fields such as oncology, neuroscience, and immunology, mass spec protein analysis is applied to explore disease mechanisms, identify disease-related biomarkers, and study pathological processes.

 

3. Drug Development: Mass spec protein analysis can also be utilized for target validation, optimization of drug candidates, analysis of drug-protein interactions, and quality control of biopharmaceuticals, enhancing the efficiency and success rate of drug development.

 

FAQ

1. How can the accuracy of labeled and label-free methods be ensured?

To ensure the accuracy of labeled and label-free methods, it is essential to optimize experimental design, strictly control sample preparation conditions, select efficient labeling reagents, and validate labeling efficiency. High-performance mass spectrometry and validated algorithms should be employed for data analysis, with results calibrated using internal standards or external references to ensure accuracy and reproducibility.

 

Deliverables

1. Comprehensive Experimental Details

2. Materials, Instruments, and Methods

3. Relevant Liquid Chromatography and Mass Spectrometry Parameters

4. The Detailed Information of Mass Spec Protein Analysis 

5. Mass Spectrometry Image

6. Raw Data

 

If you are interested in our mass spec protein analysis service or other related services, please contact us freely.