Is There a Difference Between Using UniProt for Protein Annotation and Converting Protein IDs to Gene IDs for GO/KEGG Analysis?
The use of protein IDs for GO/KEGG enrichment analysis and the conversion of protein IDs to gene IDs for analysis may produce similar results; however, some differences still exist.
UniProt primarily focuses on providing detailed functional, structural, and interaction annotations for individual proteins. In contrast, GO/KEGG enrichment analysis aims to identify biological functions or pathway enrichment patterns within a set of genes or proteins.
When investigating the characteristics of a specific protein, UniProt can be utilized. However, when analyzing the biological processes or pathways that a set of proteins or genes may be involved in, GO or KEGG enrichment analysis is more appropriate.
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