Integrative Transcriptomics-PTM ProteomicsAnalysis
- Advance Analysis Platform: MtoZ Biolabs established an advanced multi-omics analysis platform, guaranteeing reliable, fast, and highly accurate analysis service.
- One-Time-Charge: Our pricing is transparent, no hidden fees or additional costs.
- High-Data-Quality: Deep data coverage with strict data quality control. AI-powered bioinformatics platform integrate all multi-omics analysis data providing clients with a comprehensive data report.
- Customized Service: Tailored to the specific research needs of our clients, we offer flexible experimental design and personalized data analysis to ensure the achievement of research goals to the fullest extent.
- Disease Mechanism Research: Uncovering expression changes in disease-related genes and protein modifications.
- Drug Development: Assessing the impact of drugs on transcriptomics and PTM, while screening potential targets.
- Biomarker Discovery: Identifying potential disease biomarkers through combined analysis.
- Metabolic Pathway Studies: Gaining deeper insights into interactions between genes and proteins within metabolic pathways.
Transcriptomics is the discipline that studies all RNA molecules expressed by cells under specific conditions. By analyzing the transcriptome, researchers can obtain insights into changes in gene expression levels, revealing regulatory mechanisms within cells. Post-Translational modification (PTM) proteomics investigates various chemical modifications that proteins undergo after synthesis, such as phosphorylation, acetylation, and ubiquitination, significantly impacting their function, stability, and interactions among proteins.
The combined analysis of transcriptomics and PTM proteomics offers unique advantages. The transcriptome provides a comprehensive overview of gene expression, while PTM proteomics delves into the functional regulation of proteins. By integrating data from both, a multi-layered regulatory network from transcription to modification can be revealed, offering a more complete biological map. This combined analysis not only clarifies differences between gene expression and protein function but also elucidates molecular mechanisms underlying disease development and aids in identifying new drug targets.
Analysis Workflow
MtoZ Biolabs' combined analysis service for transcriptomics-PTM proteomics integrates high-throughput RNA sequencing (RNA-Seq) and mass spectrometry techniques, employing the following steps for comprehensive sample analysis:
1. Sample Preparation
Extract RNA and proteins to ensure quality and purity.
2. Transcriptome Analysis
Utilize RNA-Seq technology to sequence the extracted RNA and analyze gene expression levels and their variations.
3. Proteomics Analysis
Conduct mass spectrometry on the extracted proteins to identify and quantify them, while detecting their post-translational modifications.
4. Data Integration and Analysis
Integrate data from transcriptomics and PTM proteomics for systems biology analysis.
Service Advantages
Why Choose MtoZ Biolabs?
Applications
Application Case
KAT6A mutations in patient-derived dermal fibroblasts undergo multi-omic profiling
Singh, M. et al. Hum. Genet. 2023.
Deliverables
What Could be Included in the Report?
1. Comprehensive Experimental details
2. Materials, Instruments, and Methods
3. Total Ion Chromatogram & Quality Control Assessment (project-dependent)
4. Data Analysis, Preprocessing, and Estimation (project-dependent)
5. Bioinformatics Analysis
6. Raw Data Files
MtoZ Biolabs, an integrated Chromatography and Mass Spectrometry (MS) Services Provider, provides advanced proteomics, metabolomics, and multi-omics analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. Our ultimate aim is to provide more rapid, high-throughput, and cost-effective analysis, with exceptional data quality and minimal sample consumption. For any inquiries or requirements, please contact us.
How to order?
