How Can the Metabolic Pathways of a Specific Species Be Identified Using KEGG?
To identify the metabolic pathways of a specific species using KEGG (Kyoto Encyclopedia of Genes and Genomes), the following steps can be followed:
1. Access the KEGG database at https://www.kegg.jp/ and navigate to the "Pathway" section.
2. Enter the name of the target species (e.g., Homo sapiens) in the search bar.
3. Click the "Search" button to retrieve metabolic pathway data associated with the species.
4. The results page will display various categories of metabolic pathways, such as carbon metabolism and nitrogen metabolism. Select the relevant category to explore specific pathways.
5. On the pathway page, key details including the pathway name, graphical representation, associated genes, enzymes, and metabolic products will be provided.
6. To obtain more detailed information, click on individual components within the pathway diagram, such as enzymes or metabolic intermediates.
7. KEGG also provides analytical tools for deeper exploration of metabolic pathways. For example, KEGG Pathway Mapper can be used for pathway visualization and analysis, while KEGG BRITE enables hierarchical classification of genes and enzymes involved in metabolic processes.
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