HK Analysis Service

HK (3-Hydroxykynurenine) is an intermediate product in the tryptophan metabolism pathway, with its chemical structure formed by the hydroxyl substitution on the kynurenine molecule. HK is primarily derived from the oxidation of kynurenine, which is produced by the action of indoleamine 2,3-dioxygenase (IDO) or tryptophan 2,3-dioxygenase (TDO) on tryptophan. HK is highly oxidative and plays a role in oxidative stress responses, potentially causing oxidative damage in the nervous system. Its metabolites include kynurenic acid and xanthurenic acid, the latter of which exhibits antioxidant properties and may provide neuroprotection. Analyzing the levels of HK and its metabolites in plant and biological samples is crucial for studying tryptophan metabolism, neurodegenerative diseases, and related therapeutic pathways.

 



Figure 1. The Structure of HK

 

MtoZ Biolabs, an integrated chromatography and mass spectrometry (MS) services provider, provides advanced metabolomics, proteomics and biopharmaceutical analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. Our ultimate aim is to provide more rapid, high-throughput, and cost-effective analysis, with exceptional data quality and minimal sample consumption. MtoZ Biolabs provides a comprehensive HK Analysis Service, employing our advanced liquid chromatography-mass spectrometry (LC-MS) based metabolomics research platform. We ensure the accuracy of quantification, along with the comprehensive and precise identification of HK and its metabolites.

 

Analysis Workflow

 



 

Service Advantages

1. Advance Analysis Platform: MtoZ Biolabs established an advanced HK analysis platform, guaranteeing reliable, fast, and highly accurate analysis service.

 

2. One-Time-Charge: Our pricing is transparent, no hidden fees or additional costs.

 

3. High-Data-Quality: Extensive data coverage with rigorous quality control. Our advanced analysis platform consolidates all HK analysis data, delivering clients a detailed and comprehensive data report.

 

4. Quick Turnaround: We offer a fast analysis process to ensure that clients receive high-quality data within a short time.

 

Applications

• Pharmacokinetics and bioavailability studies
• Metabolic pathway research
• Drug metabolism studies
• Nutraceutical and functional food research

 

Sample Submission Requirements

• Sample Types: Serum, plasma, urine, tissues (animal tissue ≥ 100 mg, plant tissue ≥ 200 mg)
• Sample Volume: Serum/ Plasma ≥ 200 μL, Urine ≥ 2 mL
• Sample Preservation: Store at -80°C for stability

 

Note: Please provide details on sample collection and handling.

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on HK

4. Raw Data

5. Custom Analysis Report

 

Through our HK Analysis Service, we aim to facilitate your research and product development by providing accurate and reliable results. For more information and service inquiries, please feel free to contact us at MtoZ Biolabs.