Gut Metabolomics Analysis Service
- Chronic Metabolic Disease Research: Investigate the role of gut metabolites in the development and progression of chronic metabolic diseases such as obesity and type 2 diabetes.
- Gut Barrier and Immune Homeostasis: Study how gut metabolites influence the functionality of the gut barrier and mucosal immune system.
- Dietary and Nutritional Studies: Analyze the interaction between dietary components and microbial metabolites to explore the impact of diet on gut metabolism, supporting research in nutritional interventions and health management.
- Pharmacometabolomics: Evaluate the effects of pharmaceutical interventions on gut metabolites, optimizing drug efficacy and safety through gut metabolomics analysis.
Gut metabolomics refers to the analysis of terminal and intermediate metabolites generated by specific metabolic processes occurring within the gut. These metabolites are critical in maintaining immune-metabolic homeostasis, facilitating mutualistic interactions between the host and microbiota, and providing defense against pathogenic organisms. The primary sources of these metabolites are dietary inputs and microbial metabolic activities. These metabolites fulfill essential physiological roles, including regulation of fat storage, glucose metabolism, immune modulation, and endocrine function. Additionally, gut metabolites not only influence local gut barrier integrity and mucosal immune equilibrium but can also traverse the intestinal epithelium via active or passive transport, exerting regulatory effects on extraintestinal tissues.
Key metabolites such as short-chain fatty acids (SCFAs), trimethylamine N-oxide (TMAO), choline, conjugated linoleic acid, secondary bile acids, and phenolic compounds are derived from dietary components or synthesized by gut microbes through various metabolic pathways. The production of these metabolites is shaped by dietary nutrients and bioactive compounds like phytochemicals. Research has increasingly demonstrated that alterations in gut metabolite profiles are strongly linked to the pathogenesis of chronic metabolic disorders, including obesity and type 2 diabetes. As a result, comprehensive analysis of gut metabolites not only advances our understanding of disease mechanisms but also presents novel therapeutic targets for personalized medicine approaches. MtoZ Biolabs offers an extensive range of Gut Metabolomics Analysis Service, aimed at empowering researchers to explore the intricate relationships between gut metabolites and host health, thereby contributing to disease research.
Analysis Workflow
Xin, L. et al. J. Pharm. Biomed. Anal. 2024.
Service Advantages
1. High Sensitivity and Precision
Our LC-MS/MS platform is capable of detecting even low-abundance metabolites, ensuring a high degree of accuracy and reproducibility in data outputs.
2. Comprehensive Metabolite Profiling
The platform offers extensive coverage, analyzing a wide spectrum of metabolites including SCFAs, bile acids, and TMAO, thus providing a holistic view of the gut metabolic network.
3. Tailored Analytical Solutions
We offer customized metabolomics analysis plans designed to meet the specific objectives and requirements of diverse research projects.
4. Rapid Turnaround Time
With streamlined workflows and advanced data processing capabilities, we deliver high-quality research results promptly, facilitating the swift progression of scientific research.
Sample Submission Requirements
For more sample details, please consult our technical team.
Applications
Deliverables
What Could be Included in the Report?
1. Comprehensive Experimental details
2. Materials, Instruments, and Methods
3. Total Ion Chromatogram & Quality Control Assessment (project-dependent)
4. Data Analysis, Preprocessing, and Estimation (project-dependent)
5. Bioinformatics Analysis
6. Raw Data Files
MtoZ Biolabs, an integrated Chromatography and Mass Spectrometry (MS) Services Provider, provides advanced proteomics, metabolomics, and biopharmaceutical analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. Our ultimate aim is to provide more rapid, high-throughput, and cost-effective analysis, with exceptional data quality and minimal sample consumption. Free project evaluation, welcome to learn more details!
How to order?
