Ginkgolides Analysis Service

Ginkgolides are a class of sesquiterpene lactones extracted from the leaves of Ginkgo biloba, including several key subtypes such as ginkgolide A, B, C, and J. Known for their distinctive chemical structures and diverse biological activities, these compounds exhibit significant effects in neuroprotection, anti-inflammatory responses, antioxidant activity, and vasodilation. Among them, ginkgolide B is particularly notable for its potent anti-atherosclerotic effects. Recent studies (reference: "Anti-atherosclerotic effects and molecular targets of ginkgolide B from Ginkgo biloba", Acta Pharm Sin B, 2024) have shown that ginkgolide B modulates the PAF pathway, effectively inhibiting platelet aggregation and vascular inflammation, thus providing cardiovascular protective benefits. Furthermore, ginkgolide B has been found to regulate immune responses and suppress oxidative stress, contributing to the mitigation of chronic disease progression. These properties make ginkgolide B a valuable focus for further research in drug development and clinical applications. 



Ye, W. L. et al. Acta Pharm Sin B. 2024.

Figure 1. Ginkgo Biloba L. and its Major Active Ginkgolide Compounds' Chemical Structures

 

MtoZ Biolabs utilizes state-of-the-art liquid chromatography-tandem mass spectrometry (LC-MS/MS) to deliver highly sensitive quantitative analysis of ginkgolides and their subtypes. Our services enable researchers to precisely measure ginkgolide concentrations in a variety of samples, ensuring data accuracy and reliability. This analytical support is crucial for applications in drug development, functional food production, and broader biological research.

Analysis Workflow

 



 

Service Advantages

Why Choose MtoZ Biolabs?

1. Advance Analysis Platform: MtoZ Biolabs established an advanced targeted metabolomics analysis platform, guaranteeing reliable, fast, and highly accurate analysis service.

2. One-Time-Charge: Our pricing is transparent, no hidden fees or additional costs.

3. High-Data-Quality: Deep data coverage with strict data quality control. AI-powered bioinformatics platform integrate all targeted metabolomics analysis data providing clients with a comprehensive data report.

4. Multi-Sample Compatibility: Our platform supports a wide variety of sample types, including plasma, urine, tissue samples, plant extracts, and functional foods.

5. Customized Service: Tailored to the specific research needs of our clients, we offer flexible experimental design and personalized data analysis to ensure the achievement of research goals to the fullest extent.

 

Sample Submission Requirements

 



 

Applications

1. Drug Development and Efficacy Evaluation: Supports the analysis of ginkgolide pharmacokinetics and pharmacodynamics, facilitating the development of new therapeutic agents.

2. Functional Food Development: Provides accurate quantification of ginkgolides in dietary supplements, ensuring product quality and consistency.

3. Cardiovascular Disease Research: Enables the study of ginkgolide B's effects on cardiovascular health, particularly in the context of atherosclerosis prevention and therapy.

4. Anti-inflammatory and Immune Modulation Research: Assists in exploring the potential of ginkgolides to modulate inflammatory pathways and immune responses.

5. Phytochemical Analysis: Offers precise measurements of ginkgolide content in plant extracts, supporting research into their natural product chemistry and bioactivity.

 

Deliverables

1. Comprehensive Experimental Details

2. Materials, Instruments, and Methods

3. Total Ion Chromatogram & Quality Control Assessment

4. Data Analysis, Preprocessing, and Estimation

5. Bioinformatics Analysis

6. Raw Data Files

 

MtoZ Biolabs is committed to delivering precise and reliable Ginkgolides Analysis Service of the highest quality. By incorporating the latest advancements in ginkgolide research, we continually refine our technical processes to provide robust support for your scientific endeavors. For further details about our services and collaboration opportunities, please contact us. We look forward to collaborating with you to advance ginkgolide research.