Flower-derived Exosome Research and Applications

Flower-derived exosomes (FDEs) are nano-sized lipid bilayer vesicles naturally secreted by plant cells, with diameters of approximately 30–200 nm. FDEs are a specialized subclass of plant-derived extracellular vesicles (P-EVs). While both share core characteristics like natural low immunogenicity and high biocompatibility, FDEs exhibit enhanced anti-inflammatory, antioxidant, and targeted delivery potential due to their unique floral secondary metabolites (e.g., polyphenols, flavonoids) and bioactive enzymes. Rich in functional proteins, lipids, RNAs, and secondary metabolites (such as polyphenols and flavonoids), they serve as “natural messengers” in plant communication with the external environment or across species. By delivering bioactive molecules to regulate host cell functions, FDEs play significant roles in anti-inflammatory, antioxidant, tissue repair, and immune modulation processes. Compared to mammalian exosomes, FDEs offer several unique advantages:

1. Naturally Low Immunogenicity: They avoid the risk of immune rejection associated with animal-derived exosomes.

2. Diverse Sources: Abundant floral resources such as roses, chamomile, and chrysanthemums allow for large-scale extraction.

3. Eco-friendly: Plant extraction processes are low-carbon and sustainable, aligning with the biopharmaceutical industry's shift towards greener practices.

4. Multifunctional Potential: They possess both direct therapeutic effects (e.g., anti-tumor) and serve as platforms for drug delivery.

 



Jin, Z. et al. Heliyon. 2024.

Figure 1. Pharmacological Effects of Plant-Derived Exosome-Like Nanoparticles

 

MtoZ Biolabs provides a one-stop solution for flower-derived exosome research and applications, supporting clients in accelerating new drug development, innovative functional skincare product creation, and the design of precision medicine strategies. Our offerings include:

1. FDEs Basic Research and Structural Analysis

• Isolation and purification (ultracentrifugation/size exclusion chromatography)
• Physical characterization (particle size, zeta potential, stability)
• Component identification (lipidomics, proteomics, metabolomics)

 

2. Functional Validation and Mechanism Exploration

• In vitro assays for anti-inflammatory, antioxidant, and pro-migration activities (cell models)
• In vivo efficacy evaluation (using mouse/rat disease models)
• Signal pathway detection (Western Blot, qPCR, immunofluorescence)

 

3. Delivery System Development and Optimization

• Development of drug/gene loading processes
• Targeted modification (ligand conjugation, membrane engineering)
• Stability testing for oral/injectable formulations

 

4. Preclinical Research Support

• Toxicology assessment (acute/subacute toxicity)
• Pharmacokinetics analysis (distribution, metabolism, excretion)
• Scalable production and quality control (ISO certification system)

 



Zhang, Z. et al. Front Immunol. 2022.

Figure 2. Scheme of Isolation and Purification of Plant-Derived Exosome-Like Nanoparticles

 

Why Choose MtoZ Biolabs?

1. Core Technological Barriers

• High-Purity Extraction Technology: Enhanced plant cell disruption and gentle separation processes ensure the complete preservation of FDEs bioactivity (viability >95%).
• High-Throughput Characterization Platform: Combining NanoSight and mass spectrometry analyses, we have established a component-function correlation database to support targeted development.

 

2. Full-Chain Service Capability

• From Laboratory to Industrialization: We optimize FDEs scalable production processes at the hundred-batch level to meet preclinical to IND submission requirements.
• Interdisciplinary Team: Botanists, nano-medicine experts, and pharmacologists collaboratively tackle mechanism and translational challenges.

 

3. Personalized Solutions

• Customized Plant Varieties: We select the best floral sources based on target functions (e.g., anti-allergic, wound healing).
• Enhanced Functional Design: Surface modification techniques are developed based on targeting needs.

 

Applications

1. Flower-Derived Exosome can be Applied in Periodontitis Treatment

 



Zhang, Z. et al. Front Immunol. 2022.

Figure 3. Scheme of PELNs’ Application in the Treatment of Periodontitis

 

2. Plant-Derived Extracellular Vesicles as a Novel Nanomedicine

 



Nemati, M. et al. Cell Commun Signal. 2022.

Figure 4. Potential Therapeutic Application of P-EVs in Medicine

 

Flower-derived exosomes (FDEs), as a bridge connecting nature and medicine, are spearheading the next generation of precision therapies and eco-friendly cosmeceuticals. With deep technological expertise and full-chain service capabilities, MtoZ Biolabs is dedicated to transforming the natural wisdom of the plant kingdom into practical medical solutions. Whether you are an innovative pharmaceutical company, a biotechnology firm, or a functional skincare brand, we offer customized strategies to help you seize the high ground in FDE research and development. Contact MtoZ Biolabs, and let’s unlock the extraordinary potential of this natural nano-treasure together!