• Home
  • Biopharmaceutical Research Services
  • Multi-Omics Services
  • Support
  • /assets/images/icon/icon-email-2.png

    Email:

    info@MtoZ-Biolabs.com

    Effects of Glycosylation Modification on Antibodies

      Glycosylation modification is a chemical modification process on biomolecules, involving the combination of sugar molecules with other biomolecules (usually proteins). This modification process plays a crucial regulatory role within the organism, particularly in terms of protein function and stability.

       

      Glycosylation modifications also impact antibodies, manifested in the following ways:

       

      Antibody Stability

      Glycosylation modification can influence the stability of antibodies, making them more resistant to proteolytic degradation, thereby prolonging the lifespan of the antibodies.

       

      Immunogenicity

      Glycosylation modification can alter the immunogenicity of the antibody, causing different immune responses in the immune system. This could lead to the antibody being identified and cleared more easily by the immune system, or enhance its potency.

       

      Functionality

      Glycosylation modification can also affect the functionality of the antibody. For instance, glycosylation modification can regulate the affinity of the antibody, affecting its binding capability with the target protein. This is crucial for antibody design in drug research and therapeutic applications.

       

      Biodistribution

      Glycosylation modification can also influence the distribution and clearance rate of the antibody within the organism. Some glycosylation patterns can cause the antibody to be cleared more easily by the liver or kidneys, while others may extend the circulation time of the antibody within the body.

    Submit Inquiry
    Name *
    Email Address *
    Phone Number
    Inquiry Project
    Project Description *

     

    How to order?


    /assets/images/icon/icon-message.png

    Submit Inquiry

    /assets/images/icon/icon-return.png