DL-Mevalonic Acid Lactone Analysis Service
- Extensive expertise in handling various biological samples and extracting metabolites.
- State-of-the-art mass spectrometry platforms.
- Strict quality control to ensure reliable results.
- Comprehensive statistical and bioinformatics analysis.
- Personalized service to meet various research needs.
- Detection of potential disease biomarkers
- Enhancement of disease diagnosis
- Acceleration in the discovery of novel therapeutics
- Revelation of new insights into disease progression and mechanisms
- Animal tissue ≥ 100 mg
- Plant tissue ≥ 200 mg
- Serum/ Plasma ≥ 200 μL
- Urine ≥ 2 mL
DL-Mevalonic acid lactone is the lactone form of mevalonic acid, formed through the spontaneous cyclization of mevalonic acid, which is produced from 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) by the action of HMG-CoA reductase. Inside cells, DL-mevalonic acid lactone can be hydrolyzed back to mevalonic acid, which then undergoes a series of phosphorylation reactions to form isopentenyl pyrophosphate (IPP), the fundamental building block for the synthesis of isoprenoids and cholesterol. This metabolic pathway is tightly regulated and plays a crucial role in the synthesis of cholesterol and related molecules, impacting cell membrane structure, hormone synthesis, and cell signaling. Defects in the mevalonate pathway can lead to rare metabolic disorders, such as mevalonic aciduria, characterized by symptoms like fever, abdominal pain, developmental delay, and neurological manifestations. Monitoring levels of DL-mevalonic acid lactone in patients can aid in the early diagnosis and management of such conditions. The successful use of drugs targeting the mevalonate pathway, such as statins, in treating cardiovascular and other metabolic diseases further indicates that deeper research into DL-mevalonic acid lactone and its related metabolites may help develop new therapeutic strategies.
Figure 1. The Structure of DL-Mevalonic Acid Lactone
DL-Mevalonic acid lactone is a pivotal metabolite in the biosynthesis of sterols and other isoprenoids, with significant implications in various biological and disease processes. At MtoZ Biolabs, we offer top-notch DL-Mevalonic Acid Lactone Analysis Service, backed by our sophisticated liquid chromatography-mass spectrometry (LC-MS) platform and expert metabolomics team. Our service ensures thorough and accurate analysis, with the utmost sensitivity.
Analysis Workflow
Service Advantages
Applications
Sample Submission Requirements
1. Sample Types
Serum, plasma, urine, tissues, and other biological samples are accepted. It's essential to provide more than three materials under similar conditions for each sample.
2. Sample Volume
3. Sample Preservation
To maintain stability, store samples at -80°C.
Note: Please provide information on how samples were collected and handled.
Deliverables
1. Experimental Procedures
2. Relevant Liquid Chromatography and Mass Spectrometry Parameters
3. Detailed Information on DL-Mevalonic Acid Lactone
4. Raw Data
5. Custom Analysis Report
Our DL-mevalonic acid lactone analysis service aims to enable your research and product development processes by delivering precise and reliable results. If you have any questions or would like to learn more about our analysis services, please feel free to contact us. We look forward to collaborating with you to advance scientific research and clinical applications.
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