Ceramides Analysis Service

Ceramides (Cers) are a class of lipophilic lipid molecules composed of sphingosine and fatty acids linked by an amide bond. As a fundamental component of eukaryotic cell membranes, Cers are highly concentrated within the cell membrane and are integral to sphingomyelin, contributing to membrane stability and structural integrity. In addition to their widespread presence in the skin—where they play a crucial role in maintaining the skin barrier—Cers are involved in various physiological functions of the cell membrane.

 



Figure 1. Molecular Structure of Ceramides

 

Recent studies have revealed that Cers function beyond being structural elements of cell membranes; they actively participate in the regulation of multiple cellular signaling pathways, such as those governing cell differentiation, proliferation, apoptosis, and programmed cell death (PCD). Furthermore, Cers are key regulators of cellular stress responses, metabolic balance, and inflammatory processes. Fluctuations in ceramide levels are closely associated with metabolic disorders (e.g., diabetes and obesity), neurodegenerative diseases (e.g., Alzheimer's and Parkinson's), and cardiovascular conditions, making them valuable biomarkers for disease research.

  

Summers, S. A. et al. Nat. Metab. 2019.

Figure 2. Target Tissues and Metabolic Activities of Ceramides

 

MtoZ Biolabs, utilizing advanced liquid chromatography-tandem mass spectrometry (LC-MS/MS), offers high-sensitivity analysis of ceramides. Our services enable precise quantification of Cers and their metabolic profiles in various samples, addressing the needs of both basic research and clinical applications, including drug discovery, metabolic disease studies, and skin health research. Through our cutting-edge technology platform, researchers can obtain detailed insights into the dynamic changes of Cers in biological samples, providing robust data support for scientific investigations.

 

Analysis Workflow

 



 

Services at MtoZ Biolabs

 



 

Service Advantages

Why Choose MtoZ Biolabs?

1. Advance Analysis Platform: MtoZ Biolabs established an advanced targeted metabolomics analysis platform, guaranteeing reliable, fast, and highly accurate analysis service.

2. One-Time-Charge: Our pricing is transparent, no hidden fees or additional costs.

3. High-Data-Quality: Deep data coverage with strict data quality control. AI-powered bioinformatics platform integrate all targeted metabolomics analysis data providing clients with a comprehensive data report.

4. Multi-Sample Compatibility: Our platform supports a wide variety of biological samples, including cells, tissues, blood, and bodily fluids, providing flexibility to accommodate diverse research demands.

5. Customized Service: Tailored to the specific research needs of our clients, we offer flexible experimental design and personalized data analysis to ensure the achievement of research goals to the fullest extent.

 

Sample Submission Requirements

 



 

Deliverables

What Could be Included in the Report?

1. Comprehensive Experimental Details

2. Materials, Instruments, and Methods

3. Total Ion Chromatogram & Quality Control Assessment

4. Data Analysis, Preprocessing, and Estimation

5. Bioinformatics Analysis

6. Raw Data Files

 

MtoZ Biolabs, an integrated Chromatography and Mass Spectrometry (MS) Services Provider, provides advanced proteomics, metabolomics, and biopharmaceutical analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. Our ultimate aim is to provide more rapid, high-throughput, and cost-effective analysis, with exceptional data quality and minimal sample consumption. Free project evaluation, welcome to learn more details!