Cardiovascular Disease Metabolomics Service

    Cardiovascular disease is a major cause of death worldwide, and its pathogenesis is a hot topic for researchers. Metabolomics, as a discipline that comprehensively studies all small molecule metabolites in the body, provides a new perspective for the study of cardiovascular disease. Through this method, we can better understand the pathogenesis of cardiovascular disease, find biomarkers for early diagnosis, and design more effective treatment plans.

     

    Cardiovascular Disease Metabolomics Service1.png

    Fine, K. S. et al. J Am Heart Assoc. 2023.

    Figure1. Cardiovascular Disease Metabolomics Analysis

     

    Services at MtoZ Biolabs

    MtoZ Biolabs has a highly professional technical team and advanced mass spectrometry equipment. Our cardiovascular disease metabolomics service includes the following steps:

    1. Collection and processing of biological samples

    2. Full spectrum scanning with high-resolution mass spectrometry

    3. Data analysis and interpretation, including Principal Component Analysis (PCA), Partial Least Squares-Discriminant Analysis (PLS-DA), etc.

    4. Propose relevant biological interpretations and predictions

     

    Our professional metabolomics services for cardiovascular disease including:

    • Analysis of metabolites related to cardiovascular diseases such as hypertension, hyperlipidemia, and diabetes;
    • Discovery of biomarkers for risk assessment and early diagnosis;
    • Research on the mechanism of cardiovascular disease drugs.

     

    Applications

    • Early diagnosis of cardiovascular diseases
    • Evaluation of treatment effects
    • The development of new drugs related to cardiovascular diseases

     

    Experimental Instruments

    Our technical platform includes:

    1. Chromatography

    • GC (Q Exactive) (- mode MS)
    • HPLC: HILIC (+/- mode MS)
    • HPLC: RP C18 (+/- mode MS)
    • IC (- mode MS)

     

    2. Mass Spectrometry

    • Q Exactive MS
    • Orbitrap Tribrid Mass Spectrometry

     

    Sample Submission Requirements

    Please provide at least 100ul of serum/plasma sample with a concentration >100ug/ul. To ensure sample quality, we recommend freezing as soon as possible after sample collection.

     

    Our technical team has rich experience and professional knowledge, and can provide you with comprehensive and accurate data analysis and result interpretation. We look forward to working with you to jointly promote the research progress of cardiovascular disease.

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