Can Protein Substances Be Detected by GC-MS
Protein substances are not typically suitable for direct analysis by gas chromatography–mass spectrometry (GC-MS), as this technique is primarily designed for volatile and semi-volatile small molecules. Due to their high molecular weight and polarity, proteins are non-volatile and thus incompatible with direct GC-MS analysis. However, under certain conditions, proteins can be chemically modified or hydrolyzed into smaller fragments, such as peptides or amino acids, which can then be derivatized and analyzed using GC-MS as protein-related derivatives.
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