Bumetanide Analysis Service

Bumetanide is a powerful loop diuretic that facilitates the excretion of sodium, chloride, and water by inhibiting the Na-K-Cl cotransporter (NKCC2) in the thick ascending limb of the loop of Henle. Known for its rapid onset of action and high potency, bumetanide is widely utilized in the management of edema associated with heart failure, renal failure, liver cirrhosis, and hypertension. Additionally, emerging research has highlighted its potential in treating neurological disorders, such as autism and epilepsy.

 

Bumetanide is primarily metabolized via hepatic pathways, with cytochrome P450 enzymes, particularly CYP3A4, playing a key role in its biotransformation. The drug is excreted through the kidneys, with a portion eliminated unchanged. Variability in individual metabolism, liver and kidney function, and drug-drug interactions can significantly impact bumetanide levels, making therapeutic drug monitoring crucial for optimizing its safety and efficacy.

 

 

Figure 1. Molecular Structure of Bumetanide

 

Leveraging cutting-edge liquid chromatography-tandem mass spectrometry (LC-MS/MS) technology, MtoZ Biolabs offers highly sensitive quantitative analysis of bumetanide for researchers and pharmaceutical companies. Our precise quantification services support pharmacokinetic profiling, drug efficacy evaluations, and therapeutic monitoring, enhancing both drug development and clinical applications.

 

Analysis Workflow

 



 

Service Advantages

1. Advance Analysis Platform

MtoZ Biolabs established an advanced targeted metabolomics analysis platform, guaranteeing reliable, fast, and highly accurate analysis service.

 

2. One-Time-Charge

Our pricing is transparent, no hidden fees or additional costs.

 

3. High-Data-Quality

Deep data coverage with strict data quality control. AI-powered bioinformatics platform integrate all targeted metabolomics analysis data providing clients with a comprehensive data report.

 

4. Customized Service

Tailored to the specific research needs of our clients, we offer flexible experimental design and personalized data analysis to ensure the achievement of research goals to the fullest extent.

 

Sample Submission Requirements

 



 

Applications

• Pharmacokinetic research
• Drug efficacy assessment and development
• Clinical therapeutic monitoring
• Neurological disorder studies

 

Deliverables

1. Comprehensive Experimental Details

2. Materials, Instruments, and Methods

3. Total Ion Chromatogram & Quality Control Assessment (project-dependent)

4. Data Analysis, Preprocessing, and Estimation (project-dependent)

5. Bioinformatics Analysis

6. Raw Data Files