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    Biopterin Analysis Service

      Biopterin is a pteridine derivative, an important cofactor in biochemistry, primarily involved in various metabolic pathways, including the biosynthesis of neurotransmitters such as serotonin, dopamine, and nitric oxide. In living organisms, the metabolism of biopterin is closely linked to the enzymatic activities that regulate the conversion of phenylalanine, tyrosine, and tryptophan into their respective metabolites. Biopterin can exist in multiple forms, such as tetrahydrobiopterin (BH4), which is crucial for the hydroxylation reactions catalyzed by aromatic amino acid hydroxylases. These forms of biopterin are mainly excreted through urine, serving as important biomarkers for understanding metabolic diseases and neurological function. Monitoring biopterin levels and its metabolites is essential for assessing metabolic function and the safety of drugs or substances affecting cofactor-dependent enzymatic processes. Elevated or reduced levels of biopterin or its derivatives can indicate certain conditions, such as phenylketonuria, hyperphenylalaninemia, neurotransmitter disorders, or deficiencies in tetrahydrobiopterin metabolism, and may also reflect the body's response to different physiological or pharmacological interventions.

       

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      Figure 1. The Structure of Biopterin

       

      MtoZ Biolabs offers professional biopterin analysis services, supported by a high-standard technology platform and an expert metabolomics research team, ensuring the success of your research and clinical studies by providing accurate and reliable data for drug development and metabolic disorder research.

       

      Analysis Workflow

       

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      Service Advantages

      • High Sensitivity and Accuracy: With our advanced LC-MS platform, we ensure high sensitivity and accuracy in the detection and quantification of biopterin.
      • Expert Team: Our team comprises experts in the field of metabolomics, ensuring reliable results.
      • Comprehensive Analysis: We do not just provide the biopterin concentration but also offer insight into its possible metabolic pathways.

       

      Applications

      • Qualitative and quantitative analysis of biopterin in various biological samples.
      • Investigation of biopterin metabolism.
      • Studies on the role of biopterin in various diseases and conditions.

       

      Sample Submission Requirements

      1. Sample Types

      We accept a wide range of biological samples including serum, plasma, urine, and tissues. A minimum of 3 samples with the same condition is required for each analysis.

       

      2. Sample Volume

      • Animal tissue ≥ 100 mg
      • Plant tissue ≥ 200 mg
      • Serum/ Plasma ≥ 200 μL
      • Urine ≥ 2 mL

       

      3. Sample Preservation

      Samples should be stored at -80°C to maintain stability. Please provide details on sample collection and handling.

       

      Deliverables

      1. Experimental Procedures

      2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

      3. Detailed Information on Biopterin

      4. Raw Data

      5. Custom Analysis Report

       

      With our biopterin analysis service, we aim to support your research and product development efforts by providing accurate and reliable results. Trust MtoZ Biolabs for your comprehensive biopterin analysis needs.

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