Biomarker Metabolomics Analysis

Biomarkers are measurable indicators within the body that reflect physiological or pathological states, or pharmacological responses to therapeutic drugs. Biomarker metabolomics analysis, a subset of metabolomics, focuses on detecting specific metabolic changes in biological samples such as blood, urine, or tissue. These changes may be associated with particular pathological states or can predict the bioactivity of drugs. Such analyses are invaluable for understanding disease mechanisms, optimizing treatment protocols, and advancing personalized medicine. Through mass spectrometry, MtoZ Biolabs can precisely identify and quantify a wide range of metabolites within the body, providing critical data for disease diagnosis, treatment monitoring, and new drug development.

 



McGranaghan, P. et al. Metabolites. 2021.

Figure1. General Metabolomic Approach for Biomarker Analysis

 

Services at MtoZ Biolabs

MtoZ Biolabs utilizes High-Performance Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) technology, coupled with advanced data processing software, to perform qualitative and quantitative analyses. Our analysis process includes:

1. Sample collection: including serum, plasma, urine, tissue, etc.

2. Sample pretreatment: including protein lipid removal, solid phase extraction, desalting, etc.

3. Analysis: Metabolites are analyzed by GC-MS, LC-MS, UPLC-MS and other mass spectrometry techniques.

4. Data processing: including mass spectrometry data correction, peak identification, quantitative analysis, etc.

 



 

Service Advantages

1. Comprehensiveness: It can screen thousands of metabolites from a single sample, providing a comprehensive method for exploring the metabolic network in the body.

2. High sensitivity: It can detect trace metabolites, even metabolites at the pg level.

3. High throughput: It can analyze multiple samples at the same time, greatly improving the efficiency of analysis.

 

Applications

• Disease diagnosis: Metabolites are direct reflections of the disease state of the body. By analyzing metabolites in the disease state, biomarkers of the disease can be found, providing a basis for disease diagnosis.
• Drug development: By analyzing the metabolites of drug action, the mechanism of action of drugs can be revealed, providing a basis for drug development.

 

Sample Submission Requirements

• Sample type: Blood, tissue, urine, cells, etc.
• Sample quantity: at least 1ml of blood and urine, at least 50mg of tissue, and at least 1×10^6 cells.
• Sample storage and transportation: stored and transported under frozen conditions.

 

MtoZ Biolabs is committed to providing efficient and precise biomarker metabolomics analysis services to researchers and enterprises. We look forward to collaborating with you to advance scientific discovery and clinical applications. For further information about our services or to discuss collaboration opportunities, please do not hesitate to contact our technical team.