Androstenedione Analysis Service

    Androstenedione, or 4-androstenedione (abbreviated as A4 or Δ4-dione), also known as androst-4-ene-3,17-dione, is a type of androgen produced by the adrenal glands and gonads, serving as a critical precursor for the synthesis of key hormones such as testosterone and estradiol. As a vital intermediate in the steroid hormone synthesis pathway, A4 plays an essential role in various physiological processes, including the development of male and female secondary sexual characteristics, maintenance of sexual function, bone health, and muscle mass regulation. Abnormal fluctuations in A4 levels are often linked to conditions like polycystic ovary syndrome (PCOS), adrenal hyperplasia, hypogonadism, and certain types of tumors. Accurate measurement of A4 is crucial for clinical diagnosis, therapeutic monitoring, and disease management.

     

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    Figure 1. Molecular Structure of Androstenedione

     

    MtoZ Biolabs offers Androstenedione Analysis Service using high performance liquid chromatography-mass spectrometry (HPLC-MS). This advanced method combines the separation capabilities of HPLC with the detection power of MS, ensuring high sensitivity and specificity in A4 detection.

     

    Analysis Workflow

     

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    Service Advantages

    1. High Sensitivity and Precision

    HPLC-MS/MS provides highly sensitive and accurate measurements, suitable for detecting low concentrations of A4.

     

    2. Rapid and Efficient

    Optimized sample preparation and fast analysis ensure quick and efficient processing.

     

    3. Wide Applicability

    Suitable for various biological samples, including blood, urine, and tissues.

     

    4. Accurate and Reliable Data

    Ensures high reproducibility and low error rates, supporting both research and clinical applications, providing reliable and specific results.

     

    Sample Submission Requirements

    Make sure the sample volume is greater than 0.2 g or 0.2 mL. For detailed sample submission information, please contact our customer service.

     

    Applications

    • Measure A4 levels to diagnose conditions such as polycystic ovary syndrome, adrenal hyperplasia, and hypogonadism.
    • Investigate the role of A4 within the endocrine system and its implications for health.
    • Assess drug effects on A4 levels to support drug development and clinical trials.
    • Research the potential of A4 as a prognostic biomarker for various diseases and its broader applications.

     

    Deliverables

    1. Experimental Procedures

    2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

    3. Detailed Information on Androstenedione

    4. Raw Data

    5. Custom Analysis Report

     

    MtoZ Biolabs is dedicated to advancing your research and clinical projects by providing detailed insights into A4's extensive physiological roles through top-tier analytical techniques and expert services.

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