9S,11R-dihydroxy-15-oxo-5Z,13E-prostadienoic Acid Analysis Service
- Quantification of 9S,11R-dihydroxy-15-oxo-5Z,13E-prostadienoic acid: Accurate measurement of its concentration in various samples.
- Metabolic pathway study: Understanding how this metabolite is produced and degraded in the body.
- Discovery of potential biomarkers: Identification of new biomarkers related to diseases.
- Biomedical research
- Clinical diagnostics
- Drug discovery and development
- Animal tissue ≥ 100 mg
- Plant tissue ≥ 200 mg
- Serum/ Plasma ≥ 200 μL
- Urine ≥ 2 mL
9S,11R-dihydroxy-15-oxo-5Z,13E-prostadienoic acid, also known as 15-Keto-prostaglandin F2α, is a major metabolite of prostaglandin F2α (PGF2α), formed through the oxidation of the 15-hydroxyl group by the enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH). This enzyme is found in various tissues such as the lung, kidney, and placenta, where it catalyzes the NAD- or NADP-dependent dehydrogenation of PGF2α, leading to the formation of 15-keto-PGF2α. This metabolic process is a key step in the inactivation and regulation of prostaglandin signaling.
Once formed, 15-keto-prostaglandin F2α undergoes further metabolism, including delta13-reduction, beta-oxidation, and omega-oxidation, eventually yielding the ultimate metabolite, 5α,7α-dihydroxy-11-keto-tetranorprosta-1,16-dioic acid, which is excreted in urine. This metabolic pathway highlights the crucial role of prostaglandin degradation in maintaining physiological homeostasis and regulating inflammatory and reproductive processes.
15-Keto-prostaglandin F2α is an important biomarker for prostaglandin metabolism, particularly in the study of inflammation, reproductive health, and cardiovascular function. Its role as an inactivated form of PGF2α makes it a valuable target in understanding prostaglandin turnover and the regulation of prostanoid signaling pathways in various tissues. Research into 15-keto-PGF2α has implications for understanding conditions such as asthma, hypertension, and disorders related to the reproductive system.
Figure 1. The Structure of 9S,11R-dihydroxy-15-oxo-5Z,13E-prostadienoic Acid
MtoZ Biolabs, an integrated Chromatography and Mass Spectrometry (MS) Services Provider, provides advanced proteomics, metabolomics, and biopharmaceutical analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. Our ultimate aim is to provide more rapid, high-throughput, and cost-effective analysis, with exceptional data quality and minimal sample consumption. At MtoZ Biolabs, we offer a comprehensive 9S,11R-dihydroxy-15-oxo-5Z,13E-prostadienoic acid Analysis Service using advanced mass spectrometry techniques. Our services include:
Analysis Workflow
Service Advantages
1. Advance Analysis Platform
MtoZ Biolabs established an advanced 9S,11R-dihydroxy-15-oxo-5Z,13E-prostadienoic acid analysis service platform, guaranteeing reliable, fast, and highly accurate analysis service.
2. One-Time-Charge
Our pricing is transparent, no hidden fees or additional costs.
3. High-Data-Quality
Deep data coverage with strict data quality control. AI-powered bioinformatics platform integrate all 9S,11R-dihydroxy-15-oxo-5Z,13E-prostadienoic acid analysis service data providing clients with a comprehensive data report.
4. Fast Turnaround
The process from sample handling to report generation is efficient, shortening the analysis cycle.
Applications
Our 9S,11R-dihydroxy-15-oxo-5Z,13E-prostadienoic acid Analysis Service can be applied in the following areas:
Sample Submission Requirements
1. Sample Types
Serum, plasma, urine, tissues, and other biological samples. It is recommended to prepare at least 3 biological replicates for each sample type.
2. Sample Volume
3. Storage and Shipping
Samples should be stored at -80℃ and shipped with dry ice. Avoid repeated cycles of freezing and thawing
Note: Please provide details on sample collection and handling.
Deliverables
1. Comprehensive Experimental Details (Materials, Instruments, and Methods, etc.)
2. Relevant Liquid Chromatography and Mass Spectrometry Parameters
3. Detailed Information on 9S,11R-dihydroxy-15-oxo-5Z,13E-prostadienoic Acid
4. Raw Data
5. Custom Analysis Report
Contact us today to learn more about how our 9S,11R-dihydroxy-15-oxo-5Z,13E-prostadienoic acid Analysis Service can help advance your research.
How to order?
