8-hydroxyadenosine Analysis Service

8-Hydroxyadenosine is a crucial biomarker for oxidative stress and cellular damage, derived from the oxidation of adenosine. Structurally, 8-hydroxyadenosine is an adenosine derivative where the 8th position of the purine ring has been hydroxylated, forming a highly reactive compound. This modification results from the interaction between adenosine and reactive oxygen species (ROS), which are often produced during oxidative stress conditions.

8-hydroxyadenosine plays a significant role in assessing oxidative damage in various biological systems. It is not only a marker of oxidative stress but also an indicator of DNA damage, as it can lead to the formation of 8-hydroxydeoxyguanosine (8-OHdG), a well-known DNA lesion. The presence and concentration of 8-hydroxyadenosine can be indicative of the extent of cellular and tissue damage and provide insights into the underlying pathological conditions.

Elevated levels of 8-hydroxyadenosine have been associated with increased risk and progression of the diseases, such as cancer, cardiovascular diseases, and neurodegenerative disorders, making it a valuable biomarker for both diagnostic and prognostic purposes. The analysis of 8-hydroxyadenosine can help in understanding the mechanisms of disease development and the impact of oxidative stress on cellular health.

Figure 1. The Structure of 8-hydroxyadenosine

MtoZ Biolabs is pleased to offer our superior 8-Hydroxyadenosine Analysis Service. We utilize an advanced LC-MS/MS platform for the analysis of 8-Hydroxyadenosine. Our team of experts are capable of providing detailed insights into the levels of 8-Hydroxyadenosine in your samples, aiding you in your metabolic profiling studies.

Analysis Workflow

Service Advantages

• Continuously refined protocols and cutting-edge analytical tools  
• Expert experimental planning  
• Rapid processing times  
• Exceptional precision, selectivity, and sensitivity

Applications

Our 8-Hydroxyadenosine Analysis Service can be applied in:

• Biomarker discovery for oxidative stress-related diseases
• Metabolic profiling studies
• Drug metabolism studies

Sample Submission Requirements

• Samples should be stored at -80℃ and shipped with dry ice.
• We recommend providing at least 3 samples of similar conditions for each type of sample.
• Please provide details on sample collection and handling.
• Other sample types, please contact us for more details.

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on 8-hydroxyadenosine

4. Raw Data

5. Custom Analysis Report

Contact MtoZ Biolabs today to take advantage of our 8-Hydroxyadenosine Analysis Service. We look forward to assisting you in your research endeavors.