5S-hydroxy-6R-(S-cysteinyl)-7E,9E,11Z,14Z-eicosatetraenoic Acid Analysis Service
- Precise quantification of 5S-hydroxy-6R-(S-cysteinyl)-7E,9E,11Z,14Z-eicosatetraenoic acid
- Comprehensive report including method validation, sample preparation, and data analysis
- High reproducibility and reliability
- Biomarker discovery
- Disease diagnosis and prognosis
- Drug response prediction
- Basic biological research
- Animal tissue ≥ 100 mg
- Plant tissue ≥ 200 mg
- Serum/ Plasma ≥ 200 μL
- Urine ≥ 2 mL
5S-hydroxy-6R-(S-cysteinyl)-7E,9E,11Z,14Z-eicosatetraenoic acid, commonly known as leukotriene E4 (LTE4), is a key inflammatory mediator belonging to the cysteinyl leukotriene family. It is produced by several types of white blood cells, including eosinophils, mast cells, tissue macrophages, and basophils. Recent research has also revealed that platelets adhering to neutrophils can produce LTE4. Formed through the sequential metabolism of leukotriene C4 (LTC4) and leukotriene D4 (LTD4), LTE4 is the most stable and long-lasting of the cysteinyl leukotrienes, making it the dominant form found in biologic fluids. Due to its stability, LTE4 accumulates in various biological matrices, including breath condensation, plasma, and urine, and is frequently monitored in clinical research. Elevated levels of LTE4 have been strongly associated with respiratory diseases, particularly in patients suffering from severe asthma attacks and those with aspirin-exacerbated respiratory disease (AERD). The ability to accurately measure LTE4 in biological samples, particularly in urine, is crucial for understanding its role in these diseases and for monitoring disease progression.
Figure 1. The Structure of 5S-hydroxy-6R-(S-cysteinyl)-7E,9E,11Z,14Z-eicosatetraenoic Acid
LTE4 is believed to act through its own specific receptor, distinct from the receptors of LTC4 and LTD4, although this receptor has yet to be definitively identified. Ongoing research aims to isolate and characterize an LTE4-specific receptor, which could open new avenues for targeted therapeutic interventions.
MtoZ Biolabs, an integrated Chromatography and Mass Spectrometry (MS) Services Provider, providing advanced proteomics, metabolomics, and biopharmaceutical analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. Our ultimate aim is to provide more rapid, high-throughput, and cost-effective analysis, with exceptional data quality and minimal sample consumption. At MtoZ Biolabs, we are equipped with advanced LC-MS/MS systems for 5S-hydroxy-6R-(S-cysteinyl)-7E,9E,11Z,14Z-eicosatetraenoic acid analysis, offering you:
Analysis Workflow
Service Advantages
1. Advance Analysis Platform
MtoZ Biolabs established an advanced 5S-hydroxy-6R-(S-cysteinyl)-7E,9E,11Z,14Z-eicosatetraenoic acid analysis service platform, guaranteeing reliable, fast, and highly accurate analysis service.
2. One-Time-Charge
Our pricing is transparent, no hidden fees or additional costs.
3. High-Data-Quality
Deep data coverage with strict data quality control. AI-powered bioinformatics platform integrate all 5S-hydroxy-6R-(S-cysteinyl)-7E,9E,11Z,14Z-eicosatetraenoic acid analysis service data providing clients with a comprehensive data report.
4. Fast Turnaround
The process from sample handling to report generation is efficient, shortening the analysis cycle.
Applications
Sample Submission Requirements
1. Sample Types
Serum, plasma, urine, tissues, and other biological samples. It is recommended to prepare at least 3 biological replicates for each sample type.
2. Sample Volume
3. Storage and Shipping
Samples should be stored at -80℃ and shipped with dry ice. Avoid repeated cycles of freezing and thawing
Note: Please provide details on sample collection and handling.
Deliverables
1. Comprehensive Experimental Details (Materials, Instruments, and Methods, etc.)
2. Relevant Liquid Chromatography and Mass Spectrometry Parameters
3. Detailed Information on 5S-hydroxy-6R-(S-cysteinyl)-7E,9E,11Z,14Z-eicosatetraenoic Acid
4. Raw Data
5. Custom Analysis Report
At MtoZ Biolabs, we are dedicated to providing quality and efficient services. Our 5S-hydroxy-6R-(S-cysteinyl)-7E,9E,11Z,14Z-eicosatetraenoic acid analysis service strives to support your research with solid and accurate data.
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