5,2'-O-dimethyluridine Analysis Service
- Advanced Technology: We utilize an advanced LC-MS/MS platform for accurate and reliable analysis.
- Expert Team: Our team of experts has profound knowledge and experience in metabolomics, ensuring high-quality data interpretation.
- Comprehensive Service: We offer a one-stop service, from sample preparation to data interpretation.
- Confidentiality: All data and samples are kept strictly confidential.
- Therapeutic Development: Supports design of RNA-based drugs and therapies.
- Molecular Diagnostics: Identifying modified nucleotides in clinical samples.
- Gene Expression Analysis: Examines RNA modifications affecting gene regulation.
- Basic Biological Research: Enhances understanding of RNA metabolism and modification pathways.
- Animal tissue ≥ 100 mg
- Plant tissue ≥ 200 mg
- Serum/ Plasma ≥ 200 μL
- Urine ≥ 2 mL
5,2'-O-dimethyluridine is a unique modified nucleoside characterized by the presence of two methyl groups: one at the 5th carbon of the uracil base and another at the 2' position of the ribose sugar. This dual modification plays a critical role in enhancing the stability and functionality of RNA molecules, particularly in transfer RNA (tRNA) and ribosomal RNA (rRNA). The modification is believed to be involved in the decoding process of the genetic code by altering the codon-anticodon interaction in tRNAs. Furthermore, the dual methylation may also contribute to the regulation of gene expression and cellular responses to stress, making it an important factor in cellular homeostasis.
Research into 5,2'-O-dimethyluridine is increasingly relevant in the context of disease, particularly in cancer and metabolic disorders. Modifications in RNA, including 5,2'-O-dimethyluridine, can serve as biomarkers for various pathological conditions, offering insights into the underlying mechanisms of disease progression and treatment response. Moreover, understanding these modifications may lead to the development of novel therapeutic strategies that target RNA metabolism.
Figure 1. The Structure of 5,2'-O-dimethyluridine
At MtoZ Biolabs, we offer 5,2'-O-dimethyluridine Analysis Service based on our advanced LC-MS/MS platform. We provide comprehensive services, including sample preparation, LC-MS/MS analysis, and data interpretation.
Analysis Workflow
Service Advantages
Applications
Sample Submission Requirements
1. Sample Types
Serum, plasma, urine, tissues, and other biological samples. It is recommended to prepare at least 3 biological replicates for each sample type.
2. Sample Volume
3. Storage and Shipping
Samples should be stored at -80℃ and shipped with dry ice. Avoid repeated cycles of freezing and thawing
Note: Please provide details on sample collection and handling.
Deliverables
1. Experimental Procedures
2. Relevant Liquid Chromatography and Mass Spectrometry Parameters
3. Detailed Information on 5,2'-O-dimethyluridine
4. Raw Data
5. Custom Analysis Report
At MtoZ Biolabs, we are dedicated to providing top-quality, comprehensive, and reliable metabolomics services. Contact us today to find out how our 5,2'-O-dimethyluridine analysis service can help advance your research.
How to order?
