4D-Phosphoproteomics Service

Protein phosphorylation is one of the most critical covalent modifications in cells, regulating various biological processes such as cell proliferation, differentiation, signal transduction, apoptosis, and neural activity. This modification occurs when a phosphate group from ATP is transferred to the side chains of specific amino acids (Ser, Tyr, Thr) in proteins, a process catalyzed by kinases and tightly regulated within cells. As phosphorylation introduces a mass shift of 79.97 Da, mass spectrometry can precisely detect this shift to identify phosphorylated peptides and their modification sites.

MtoZ Biolabs offers cutting-edge 4D Phosphoproteomics Service, utilizing the timsTOF Pro mass spectrometer. By incorporating a time dimension into ion mobility separation and analyzing molecules based on their shape and cross-sectional area, this technique significantly enhances the identification depth, sensitivity, and throughput of phosphoproteomics. Our technology effectively detects low-abundance phosphorylated proteins and modification sites while minimizing sample consumption and scan time, ensuring high-quality, reliable data.

Analysis Workflow

Service Advantages

Sample Submission Requirements

For more sample details, please consult our technical team.

Applications

• Plant development and resistance to stress
• Infection and immunity research
• Aging regeneration and degenerative diseases

Deliverables

What Could be Included in the Report?

1. Comprehensive Experimental details

2. Materials, Instruments, and Methods

3. Total Ion Chromatogram & Quality Control Assessment (project-dependent)

4. Data Analysis, Preprocessing, and Estimation (project-dependent)

5. Bioinformatics Analysis

6. Raw Data Files

MtoZ Biolabs' 4D Phosphoproteomics Service provides researchers with a highly efficient and precise tool for studying phosphorylation modifications in diverse biological processes. Our advanced platform and expert services are designed to support your research and drive significant breakthroughs. Contact us for more information and customized solutions.