3,5-Diiodo-L-Thyronine Analysis Service
- Qualitative and quantitative analysis of 3,5-diiodo-L-thyronine and its metabolites.
- Determining the pharmacokinetics of 3,5-diiodo-L-thyronine.
- Providing a basis for drug development and therapeutic application.
- Animal tissue ≥ 100 mg
- Plant tissue ≥ 200 mg
- Serum/ Plasma ≥ 200 μL
- Urine ≥ 2 mL
3,5-Diiodo-L-thyronine, commonly abbreviated as T2, is a derivative of the thyroid hormone thyroxine (T4). Its chemical formula is C15H13I2NO4, with a molecular weight of approximately 525.08g/mol. Structurally, T2 consists of a phenolic ring and a tyrosine residue, with iodine atoms at the 3rd and 5th positions of the outer benzene ring. It retains the fundamental backbone of thyroxine, but specific modifications significantly impact its biological function and activity. 3,5-Diiodo-L-thyronine is of interest due to its role in metabolic regulation. Unlike the more common thyroid hormones T3 (triiodothyronine) and T4 (thyroxine), T2 acts directly on the mitochondrial membrane, affecting oxidative phosphorylation and thermogenesis. It is believed to enhance energy expenditure by activating mitochondrial uncoupling proteins and stimulating the β-oxidation of fatty acids. Recent studies suggest that T2 has a faster onset of action compared to T3 and T4, possibly due to its direct influence on mitochondrial activity rather than solely relying on nuclear receptors. Additionally, T2 is being investigated for its potential role in weight management and metabolic syndrome, as it appears to increase the basal metabolic rate without causing typical thyromimetic side effects, such as cardiac stimulation.
Figure 1. The Structure of 3,5-Diiodo-L-Thyronine
MtoZ Biolabs offers a state-of-the-art 3,5-Diiodo-L-Thyronine Analysis Service, leveraged by our advanced liquid chromatography-mass spectrometry (LC-MS) platform and an expert metabolomics team. Our service provides a comprehensive 3,5-diiodo-L-thyronine analysis, guaranteeing high sensitivity and accuracy.
Analysis Workflow
Service Advantages
1. High quality data: We deliver reliable and reproducible results with our advanced LC-MS system.
2. Expertise: Our experienced team of scientists ensures the quality and accuracy of our analysis.
3. Comprehensive report: We provide a detailed report including the experimental procedure, instrument parameters, and results interpretation.
4. Fast turnaround: The process from sample handling to report generation is efficient, shortening the analysis cycle.
Applications
Sample Submission Requirements
1. Sample Types
Serum, plasma, urine, tissues and other biological samples. A minimum of 3 replicates per condition is necessary for each sample.
2. Sample Volume
3. Sample Preservation
Samples should be stored at -80°C to maintain stability.
Note: Please include detailed information on sample collection and handling.
Deliverables
1. Experimental Procedures
2. Relevant Liquid Chromatography and Mass Spectrometry Parameters
3. Detailed Information on 3,5-Diiodo-L-Thyronine
4. Raw Data
5. Custom Analysis Report
Through our 3,5-diiodo-L-thyronine analysis service, we aim to accelerate your research and product development processes by providing accurate and trustworthy results.
How to order?
