24-Hydroxycholesterol Analysis Service

24-Hydroxycholesterol (chemical formula C₂₇H₄₆O₂) is an oxidized derivative of cholesterol, classified as an oxysterol. It has a typical steroid backbone, with a hydroxyl group (-OH) attached to the 24th carbon atom. It is primarily produced in the brain by the enzyme 24-hydroxylase (CYP46A1) and serves as a key pathway for cholesterol elimination from the central nervous system. 24-Hydroxycholesterol plays a crucial role in maintaining cholesterol balance in the brain and regulating neuronal function. It is involved in the synthesis of bile acids and steroid hormones. After metabolism, it is excreted through the liver, and its metabolites generally lack significant biological activity. Measuring 24-hydroxycholesterol levels is important in neurodegenerative diseases like Alzheimer's disease, as its analysis can help assess disruptions in cholesterol metabolism in the brain. Mass spectrometry techniques can accurately determine its concentration, providing valuable data for research and clinical applications.

 



Figure 1. The Structure of 24-Hydroxycholesterol

 

MtoZ Biolabs, an integrated chromatography and mass spectrometry (MS) services provider, provides advanced metabolomics, proteomics and biopharmaceutical analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. Our ultimate aim is to provide more rapid, high-throughput, and cost-effective analysis, with exceptional data quality and minimal sample consumption. MtoZ Biolabs delivers high-quality 24-Hydroxycholesterol Analysis Service using an advanced LC-MS-based metabolomics research platform. Our scientists offer accurate quantification of 24-hydroxycholesterol and its metabolites, ensuring comprehensive and precise metabolite identification. Should you have any interest in our 24-Hydroxycholesterol Analysis Service, don't hesitate to get in touch. We are committed to providing you with superior analytical services and technical support.

 

Analysis Workflow

 



 

Service Advantages

1. Advance Analysis Platform: MtoZ Biolabs established an advanced 24-hydroxycholesterol analysis platform, guaranteeing reliable, fast, and highly accurate analysis service.

 

2. One-Time-Charge: Our pricing is transparent, no hidden fees or additional costs.

 

3. High-Data-Quality: Extensive data coverage with rigorous quality control. Our advanced analysis platform consolidates all 24-hydroxycholesterol analysis data, delivering clients a detailed and comprehensive data report.

 

4. Quick Turnaround: We offer a fast analysis process to ensure that clients receive high-quality data within a short time.

 

Applications

• Discovering new disease biomarkers  
• Enhancing disease diagnosis  
• Speeding up the discovery of innovative therapeutics  
• Uncovering new insights into disease mechanisms

 

Sample Submission Requirements

1. Sample Types

Serum, plasma, cerebrospinal fluid, tissue samples, and other biological materials are accepted. For each sample, select more than three materials under the same conditions.

 

2. Sample Volume

• Animal tissue ≥ 100 mg
• Plant tissue ≥ 200 mg
• Serum/ Plasma ≥ 200 μL
• Urine ≥ 2 mL

 

3. Sample Preservation

For stability, store the samples at -80°C.

 

Note: Provide explicit details about sample collection and handling.

 

Deliverables

1. Experimental Procedures

2. Relevant Liquid Chromatography and Mass Spectrometry Parameters

3. Detailed Information on 24-Hydroxycholesterol

4. Raw Data

5. Custom Analysis Report

 

Our 24-Hydroxycholesterol Analysis Service strives to aid your research and product development efforts by delivering consistent and credible results.